BIOMAT Database Logo BIOMAT Database Logo

Effects of vagus nerve stimulation on pupillary function. 2015

Véronique Desbeaumes Jodoin, and Paul Lespérance, and Dang K Nguyen, and Marie-Pierre Fournier-Gosselin, and Francois Richer, and
Department of Psychology, UQAM, Canada; Department of Psychiatry, CHUM, Canada.

BACKGROUND Chronic vagus nerve stimulation (VNS) is a recognized treatment for refractory epilepsy and depression. The vagus nerve projects to several brainstem autonomic structures. As pupillary measures are an easy and non-invasive method to evaluate autonomic functioning, we used resting diameter and light reflex measures to investigate the influence of VNS on the human central autonomic nervous system. METHODS We studied 21 patients (7 with major depression, 14 with epilepsy) treated with chronic VNS (30s ON, 5 min OFF stimulation trains). Resting pupil size and light reflex measures were compared in consecutive intervals with (ON) and without stimulation (OFF). RESULTS Compared to the OFF condition, the ON condition was associated with a significant increase in resting pupil diameter, but did not affect light reflex measures. There was no group difference between the two populations of patients (depression and epilepsy) on any of the pupil measures. CONCLUSIONS VNS at clinically significant levels increases resting pupil diameter.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011680 Pupil The aperture in the iris through which light passes. Pupils
D011930 Reaction Time The time from the onset of a stimulus until a response is observed. Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D001767 Blinking Brief closing of the eyelids by involuntary normal periodic closing, as a protective measure, or by voluntary action. Orbicularis Oculi Reflex,Reflex, Blink,Reflex, Corneal,Reflex, Orbicularis Oculi,Winking,Blink Reflexes,Corneal Reflexes,Orbicularis Oculi Reflexes,Blink Reflex,Reflexes, Blink,Reflexes, Orbicularis Oculi
D003865 Depressive Disorder, Major Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5) Depression, Involutional,Major Depressive Disorder,Melancholia, Involutional,Paraphrenia, Involutional,Psychosis, Involutional,Depressive Disorders, Major,Involutional Depression,Involutional Melancholia,Involutional Paraphrenia,Involutional Paraphrenias,Involutional Psychoses,Involutional Psychosis,Major Depressive Disorders,Paraphrenias, Involutional,Psychoses, Involutional
D004827 Epilepsy A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313) Aura,Awakening Epilepsy,Seizure Disorder,Epilepsy, Cryptogenic,Auras,Cryptogenic Epilepsies,Cryptogenic Epilepsy,Epilepsies,Epilepsies, Cryptogenic,Epilepsy, Awakening,Seizure Disorders
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

Véronique Desbeaumes Jodoin, and Paul Lespérance, and Dang K Nguyen, and Marie-Pierre Fournier-Gosselin, and Francois Richer, and
[Effects of vagus nerve stimulation on memory].
January 2009, Sheng li ke xue jin zhan [Progress in physiology],
Véronique Desbeaumes Jodoin, and Paul Lespérance, and Dang K Nguyen, and Marie-Pierre Fournier-Gosselin, and Francois Richer, and
Characterization of vagus nerve stimulation-induced pupillary responses in epileptic patients.
January 2022, Brain stimulation,
Véronique Desbeaumes Jodoin, and Paul Lespérance, and Dang K Nguyen, and Marie-Pierre Fournier-Gosselin, and Francois Richer, and
Effects of vagus nerve stimulation on respiration during sleep.
October 2001, Neurology,
Véronique Desbeaumes Jodoin, and Paul Lespérance, and Dang K Nguyen, and Marie-Pierre Fournier-Gosselin, and Francois Richer, and
The effects of vagus nerve stimulation on decision-making.
January 2004, Cortex; a journal devoted to the study of the nervous system and behavior,
Véronique Desbeaumes Jodoin, and Paul Lespérance, and Dang K Nguyen, and Marie-Pierre Fournier-Gosselin, and Francois Richer, and
Acute effect of vagus nerve stimulation (VNS) on brain function.
September 2021, Journal of psychiatric research,
Véronique Desbeaumes Jodoin, and Paul Lespérance, and Dang K Nguyen, and Marie-Pierre Fournier-Gosselin, and Francois Richer, and
Cardiovascular autonomic effects of vagus nerve stimulation.
April 2019, Clinical autonomic research : official journal of the Clinical Autonomic Research Society,
Véronique Desbeaumes Jodoin, and Paul Lespérance, and Dang K Nguyen, and Marie-Pierre Fournier-Gosselin, and Francois Richer, and
Effects of stimulation of the vagus nerve on insulin secretion.
March 1967, Endocrinology,
Véronique Desbeaumes Jodoin, and Paul Lespérance, and Dang K Nguyen, and Marie-Pierre Fournier-Gosselin, and Francois Richer, and
[Vagus nerve stimulation].
March 2006, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
Véronique Desbeaumes Jodoin, and Paul Lespérance, and Dang K Nguyen, and Marie-Pierre Fournier-Gosselin, and Francois Richer, and
Vagus nerve stimulation.
November 2008, Journal of neurosurgery. Pediatrics,
Véronique Desbeaumes Jodoin, and Paul Lespérance, and Dang K Nguyen, and Marie-Pierre Fournier-Gosselin, and Francois Richer, and
Vagus nerve stimulation.
November 2008, Journal of neurosurgery. Pediatrics,
Copied contents to your clipboard!