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Angiogenic activity of latex from Euphorbia tirucalli Linnaeus 1753 (Plantae, Euphorbiaceae). 2015
G Bessa, and
P R Melo-Reis, and
L A Araújo, and
F Mrué, and
G B Freitas, and
M L Brandão, and
N J Silva Júnior
Pró-Reitoria de Pós-graduação e Pesquisa, Pontifícia Universidade Católica de Goiás, Goiânia, GO, BR.
To assess the pro-angiogenic activity of Euphorbia tirucalli, commonly known as "avelós" plant, we performed a series of tests by applying an aqueous E. tirucalli latex solution (10 mg/mL) to the chorioallantoic membranes (CAMs) of 80 fertilized chicken eggs incubated in a temperature- and humidity-controlled automatic incubator. The results indicated that the aqueous latex solution increased vascular network formation compared to that with the negative control (p < 0.05) and the inhibitor control (p < 0.05). This suggests that under the experimental conditions tested, the aqueous latex solution induced an inflammatory response leading to neoangiogenesis.
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