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The regulation of histone gene expression was examined after confluent, nondividing WI-38 human diploid fibroblasts were stimulated to proliferate. Histone mRNA sequences were assayed by hybrid formation with an 3H-labeled single-stranded DNA complementary to histone mRNAs. Histone mRNA became associated with polyribosomes concomitant with the activation of DNA synthesis. The ability of chromatin from WI-38 cells to serve as a template for in vitro transcription of histone mRNA sequences parallels the onset of DNA replication. A role for nonhistone chromosomal proteins in the control of histone gene readout is suggested because, when chromatin from confluent WI-38 cells was dissociated and then reconstituted in the presence of S phase nonhistone chromosomal proteins, a 500-fold activation of histone mRNA sequence transcription was observed.
R L Jansing, and
J L Stein, and
G S Stein
August 1973,
FEBS letters,
R L Jansing, and
J L Stein, and
G S Stein
June 1972,
The Journal of biological chemistry,
R L Jansing, and
J L Stein, and
G S Stein
October 1974,
Experimental cell research,
R L Jansing, and
J L Stein, and
G S Stein
April 1976,
Cell differentiation,
R L Jansing, and
J L Stein, and
G S Stein
July 1974,
Biochemical and biophysical research communications,
R L Jansing, and
J L Stein, and
G S Stein
October 1976,
Science (New York, N.Y.),
R L Jansing, and
J L Stein, and
G S Stein
September 1973,
Archives of biochemistry and biophysics,
R L Jansing, and
J L Stein, and
G S Stein
July 1976,
Biochemistry,
R L Jansing, and
J L Stein, and
G S Stein
August 1975,
Biochimica et biophysica acta,
R L Jansing, and
J L Stein, and
G S Stein
June 2001,
Archives of gerontology and geriatrics,
