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To better understand the mechanisms involved in matrix development, we have analyzed the collagen synthesized by embryonic corneal epithelium, the tissue known to produce the collagenous component of the primary corneal stroma. Isolated epithelia were cultured in vitro in medium containing [oH]proline and the newly synthesized, labeled collagen was extracted, fractionally salt precipitated, and analyzed by carboxymethyl-cellulose chromatography and peptide mapping after cleavage with cyanogen bromide. The data show that the cornela epithelium produces at least two different types of collagen, one similar, if not identical, to the type I molecule of skin, and a second similar, if not identical, to the type II molecule of cartilage. Type II, heretofore, had been thought to be characteristic of cartilage extracellular matrix.
T F Linsenmayer, and
G N Smith, and
E D Hay
January 1986,
Tissue & cell,
T F Linsenmayer, and
G N Smith, and
E D Hay
March 1971,
The Journal of cell biology,
T F Linsenmayer, and
G N Smith, and
E D Hay
January 1973,
Science (New York, N.Y.),
T F Linsenmayer, and
G N Smith, and
E D Hay
December 1973,
Developmental biology,
T F Linsenmayer, and
G N Smith, and
E D Hay
June 1980,
FEBS letters,
T F Linsenmayer, and
G N Smith, and
E D Hay
March 1980,
European journal of biochemistry,
T F Linsenmayer, and
G N Smith, and
E D Hay
May 1974,
Biochemical and biophysical research communications,
T F Linsenmayer, and
G N Smith, and
E D Hay
April 1973,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
T F Linsenmayer, and
G N Smith, and
E D Hay
January 1984,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
T F Linsenmayer, and
G N Smith, and
E D Hay
May 1974,
Experimental eye research,
