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TCL1 expression patterns in Waldenström macroglobulinemia. 2016
Richard Lemal, and
Sandrine Bard-Sorel, and
Laura Montrieul, and
Jacques-Olivier Bay, and
Aurélie Ravinet, and
Albane Ledoux-Pilon, and
Nicolas Cagnard, and
Sébastien Bailly, and
Pierre Morel, and
Frédéric Charlotte, and
Xavier Leleu, and
Stéphanie Poulain, and
Pierre J Déchelotte, and
Olivier Hermine, and
Véronique Leblond, and
Olivier Tournilhac, and
Romain Guièze
CHU Clermont-Ferrand, Service d'Hématologie Clinique Adulte et de Thérapie Cellulaire, F-63003 Clermont-Ferrand, France.
The oncogenic role of TCL1 in chronic lymphocytic leukemia is well established in transgenic mice. TCL1 expression in other B-cell malignancies has been also described: post-germinal center-derived malignancies, such as multiple myeloma, classically do not express TCL1. Waldenström macroglobulinemia is a post-germinal center malignancy that is known to be similar to chronic lymphocytic leukemia in terms of its gene expression profile. TCL1 expression has not been so far assessed in Waldenström macroglobulinemia. Transcriptomic explorations show that TCL1A expression is linked to signaling pathways and biological functions that are known to be involved in Waldenström macroglobulinemia as well as to gene signatures of interest in B-cell malignancies. We investigated TCL1 expression at the protein level in the bone marrow of a series of 59 patients with Waldenström macroglobulinemia: 76% of patients expressed TCL1, which appeared to be associated with a pejorative prognostic impact. TCL1 could have an oncogenic role in Waldenström macroglobulinemia, and deserves further exploration.
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