Biomaterial Database

Management of Medication-Related Osteonecrosis of the Jaw. 2015

William Bradford Williams, and Felice O'Ryan

Division Maxillofacial Surgery, Oakland Medical Center, Kaiser Permanente, 3600 Broadway Kaiser, Oakland, CA 94611, USA.

Medication-related osteonecrosis of the jaw (MRONJ) primarily involves patients receiving intravenous bisphosphonates for treatment of skeletal-related malignancies, oral bisphosphonates, and denosumab. There is no consensus regarding the clinical management of MRONJ. Successful treatment may be that which results in a cure, with complete mucosal coverage and elimination of disease, or that which improves the quality of life without a cure (palliation). Helping patients to understand the chronicity and potential progression of the disease is essential to a satisfactory outcome. This review aims to share our treatment approach to patients with MRONJ. Treatment can be divided into medical and surgical therapies.

UI	MeSH Term	Description	Entries
D004164	Diphosphonates	Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.	Bisphosphonate,Bisphosphonates
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000069448	Denosumab	A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS.	AMG 162,Prolia,Xgeva
D050071	Bone Density Conservation Agents	Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.	Antiresorptive Agent,Antiresorptive Agents,Antiresorptive Drugs,Bone Resorption Inhibitors,Bone Resorption Inhibitory Agents,Agent, Antiresorptive,Inhibitors, Bone Resorption,Resorption Inhibitors, Bone
D059266	Bisphosphonate-Associated Osteonecrosis of the Jaw	Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process.	Bisphosphonate Osteonecrosis,Bisphosphonate-Associated Osteonecrosis,Bisphosphonate-Associated Osteonecrosis of the Jaws,Bisphosphonate-Induced Osteonecrosis of the Jaw,Bisphosphonate-Induced Osteonecrosis of the Jaws,Bisphosphonate-Related Osteonecrosis of the Jaw,Osteonecrosis of the Jaw, Bisphosphonate-Associated,Osteonecrosis of the Jaw, Bisphosphonate-Induced,Osteonecrosis of the Jaw, Bisphosphonate-Related,Osteonecrosis of the Jaws, Bisphosphonate-Associated,Osteonecrosis of the Jaws, Bisphosphonate-Induced,Osteonecrosis of the Jaws, Bisphosphonate-Related,Bisphosphonate Associated Osteonecrosis,Bisphosphonate Associated Osteonecrosis of the Jaw,Bisphosphonate Associated Osteonecrosis of the Jaws,Bisphosphonate Induced Osteonecrosis of the Jaw,Bisphosphonate Induced Osteonecrosis of the Jaws,Bisphosphonate Osteonecroses,Bisphosphonate Related Osteonecrosis of the Jaw,Bisphosphonate-Associated Osteonecroses,Osteonecroses, Bisphosphonate,Osteonecroses, Bisphosphonate-Associated,Osteonecrosis of the Jaw, Bisphosphonate Associated,Osteonecrosis of the Jaw, Bisphosphonate Induced,Osteonecrosis of the Jaw, Bisphosphonate Related,Osteonecrosis of the Jaws, Bisphosphonate Associated,Osteonecrosis of the Jaws, Bisphosphonate Induced,Osteonecrosis of the Jaws, Bisphosphonate Related,Osteonecrosis, Bisphosphonate,Osteonecrosis, Bisphosphonate-Associated
D018450	Disease Progression	The worsening and general progression of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.	Clinical Course,Clinical Progression,Disease Exacerbation,Exacerbation, Disease,Progression, Clinical,Progression, Disease