Effect of oxytocin during labor on neonatal acidemia. 2016

Serena Mussi, and Maddalena Incerti, and Cristina Plevani, and Alessandro Ghidini, and John C Pezzullo, and Anna Locatelli
a Department of Obstetrics and Gynecology , San Gerardo Hospital-FMBBM, University of Milano-Bicocca , Monza , Italy .

To assess the factors affecting neonatal acidemia, including occurrence of tachysystole/hypertonus in fetuses exposed to oxytocin during labour and with continuously-monitored fetal heart rate (FHR) tracings. Prospective observational study of all women with term pregnancies who received oxytocin for induction/augmentation of labour. FHR tracings were prospectively classified using ACOG classification. Independent predictors of neonatal acidemia were identified using multivariate linear regression with p < 0.05 considered significant. We included 430 women, 236 of whom (54.9%) had spontaneous onset of labour. The duration of active phase of the second stage of labour and the presence of abnormal FHR tracing during labour were significantly associated with UA pH (p < 0.001) and BE (p < 0.001), while maximum dose of oxytocin (p < 0.17; p < 0.7) and tachysystole (p < 0.9; p < 0.8) were not. At logistic regression, the duration of active phase of the second stage of labour was independently predictive of neonatal acidemia (p < 0.009) while abnormal FHR tracing approached significance (p < 0.088). In women receiving oxytocin during labour, the duration of active phase of the second stage of labour correlates with neonatal acidemia, whereas maximum dose of oxytocin, duration of oxytocin administration and occurrence of tachysystole during labour do not.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007744 Obstetric Labor Complications Medical problems associated with OBSTETRIC LABOR, such as BREECH PRESENTATION; PREMATURE OBSTETRIC LABOR; HEMORRHAGE; or others. These complications can affect the well-being of the mother, the FETUS, or both. Complications, Labor,Labor Complications,Complication, Labor,Complication, Obstetric Labor,Complications, Obstetric Labor,Labor Complication,Labor Complication, Obstetric,Labor Complications, Obstetric,Obstetric Labor Complication
D007748 Labor Stage, Second The period of OBSTETRIC LABOR that is from the complete dilatation of the CERVIX UTERI to the expulsion of the FETUS. Labor, Second Stage,Labor Stages, Second,Second Labor Stage,Second Labor Stages,Second Stage Labor,Stage, Second Labor,Stages, Second Labor
D007751 Labor, Induced Artificially induced UTERINE CONTRACTION. Induced Labor,Induction of Labor,Labor Induced,Labor Induction,Induced, Labor,Induction, Labor,Inductions, Labor,Labor Inductions
D010120 Oxytocics Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157) Oxytocic,Oxytocic Agent,Oxytocic Drug,Uterine Stimulant,Uterine Stimulants,Oxytocic Agents,Oxytocic Drugs,Oxytocic Effect,Oxytocic Effects,Agent, Oxytocic,Agents, Oxytocic,Drug, Oxytocic,Drugs, Oxytocic,Effect, Oxytocic,Effects, Oxytocic,Stimulant, Uterine,Stimulants, Uterine
D010121 Oxytocin A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION. Ocytocin,Pitocin,Syntocinon
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D005260 Female Females
D005333 Fetus The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN. Fetal Structures,Fetal Tissue,Fetuses,Mummified Fetus,Retained Fetus,Fetal Structure,Fetal Tissues,Fetus, Mummified,Fetus, Retained,Structure, Fetal,Structures, Fetal,Tissue, Fetal,Tissues, Fetal

Related Publications

Serena Mussi, and Maddalena Incerti, and Cristina Plevani, and Alessandro Ghidini, and John C Pezzullo, and Anna Locatelli
February 1961, La Semana medica,
Serena Mussi, and Maddalena Incerti, and Cristina Plevani, and Alessandro Ghidini, and John C Pezzullo, and Anna Locatelli
December 1984, The Journal of the American Osteopathic Association,
Serena Mussi, and Maddalena Incerti, and Cristina Plevani, and Alessandro Ghidini, and John C Pezzullo, and Anna Locatelli
May 1994, Zhonghua fu chan ke za zhi,
Serena Mussi, and Maddalena Incerti, and Cristina Plevani, and Alessandro Ghidini, and John C Pezzullo, and Anna Locatelli
January 2016, Revista latino-americana de enfermagem,
Serena Mussi, and Maddalena Incerti, and Cristina Plevani, and Alessandro Ghidini, and John C Pezzullo, and Anna Locatelli
January 2015, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians,
Serena Mussi, and Maddalena Incerti, and Cristina Plevani, and Alessandro Ghidini, and John C Pezzullo, and Anna Locatelli
January 2008, Acta obstetricia et gynecologica Scandinavica,
Serena Mussi, and Maddalena Incerti, and Cristina Plevani, and Alessandro Ghidini, and John C Pezzullo, and Anna Locatelli
March 1958, Praxis,
Serena Mussi, and Maddalena Incerti, and Cristina Plevani, and Alessandro Ghidini, and John C Pezzullo, and Anna Locatelli
June 2017, Journal of gynecology obstetrics and human reproduction,
Serena Mussi, and Maddalena Incerti, and Cristina Plevani, and Alessandro Ghidini, and John C Pezzullo, and Anna Locatelli
January 1977, Zentralblatt fur Gynakologie,
Serena Mussi, and Maddalena Incerti, and Cristina Plevani, and Alessandro Ghidini, and John C Pezzullo, and Anna Locatelli
February 1967, American journal of obstetrics and gynecology,
Copied contents to your clipboard!