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In a controlled, double-observer, multicenter study, we compared the effect of a fixed combination of timolol 0.5%-pilocarpine 4% twice a day with that of timolol 0.5% twice a day plus pilocarpine 4% three times a day in 80 patients with open-angle glaucoma whose intraocular pressure was greater than 21 mm Hg on timolol 0.5% twice a day alone. Administered twice daily, the combination drug lowered intraocular pressure as effectively as concomitant treatment with timolol twice a day and pilocarpine three times a day. No statistically significant differences in reduction of intraocular pressure were found between the two groups nor were any unexpected side effects observed.
M B Söderström, and
O Wallin, and
P A Granström, and
W Thorburn
January 1990,
American journal of ophthalmology,
M B Söderström, and
O Wallin, and
P A Granström, and
W Thorburn
June 1994,
American journal of ophthalmology,
M B Söderström, and
O Wallin, and
P A Granström, and
W Thorburn
August 1980,
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M B Söderström, and
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P A Granström, and
W Thorburn
September 1988,
American journal of ophthalmology,
M B Söderström, and
O Wallin, and
P A Granström, and
W Thorburn
December 1987,
American journal of ophthalmology,
M B Söderström, and
O Wallin, and
P A Granström, and
W Thorburn
April 1988,
American journal of ophthalmology,
M B Söderström, and
O Wallin, and
P A Granström, and
W Thorburn
August 2002,
Survey of ophthalmology,
M B Söderström, and
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P A Granström, and
W Thorburn
January 1958,
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M B Söderström, and
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P A Granström, and
W Thorburn
April 2002,
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M B Söderström, and
O Wallin, and
P A Granström, and
W Thorburn
October 1995,
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