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Knowledge of the vital role of adenosine deaminase in lymphatic tissues has led to the development of enzyme inhibitors for treatment of lymphoid neoplasms. Deoxycoformycin is a potent ADA inhibitor and has been shown to be active in acute lymphoblastic leukemia at high doses but associated with unpredictable toxicity. In indolent lymphocytic leukemia or lymphoma with low ADA concentrations, this drug is effective at low doses with mild toxicity. The on-going EORTC trial shows that pentostatin is highly effective in hairy cell leukemia and can achieve durable complete remissions even if interferon alpha has failed. It will probably play an important role in the treatment of prolymphocytic leukemia, T- and B-cell chronic lymphocytic leukemia and Sézary syndrome.
A D Ho, and
J Thaler, and
R Willemze, and
F Lauria, and
G Derossi, and
R Kuse, and
P Stryckmans, and
C M Blanc, and
F Cataldo, and
G McVie
February 1984,
Scandinavian journal of haematology,
A D Ho, and
J Thaler, and
R Willemze, and
F Lauria, and
G Derossi, and
R Kuse, and
P Stryckmans, and
C M Blanc, and
F Cataldo, and
G McVie
May 1988,
Annals of internal medicine,
A D Ho, and
J Thaler, and
R Willemze, and
F Lauria, and
G Derossi, and
R Kuse, and
P Stryckmans, and
C M Blanc, and
F Cataldo, and
G McVie
March 2005,
Haematologica,
A D Ho, and
J Thaler, and
R Willemze, and
F Lauria, and
G Derossi, and
R Kuse, and
P Stryckmans, and
C M Blanc, and
F Cataldo, and
G McVie
October 1988,
Journal of the American Academy of Dermatology,
A D Ho, and
J Thaler, and
R Willemze, and
F Lauria, and
G Derossi, and
R Kuse, and
P Stryckmans, and
C M Blanc, and
F Cataldo, and
G McVie
June 1997,
Journal of the American Academy of Dermatology,
A D Ho, and
J Thaler, and
R Willemze, and
F Lauria, and
G Derossi, and
R Kuse, and
P Stryckmans, and
C M Blanc, and
F Cataldo, and
G McVie
April 1999,
British journal of haematology,
A D Ho, and
J Thaler, and
R Willemze, and
F Lauria, and
G Derossi, and
R Kuse, and
P Stryckmans, and
C M Blanc, and
F Cataldo, and
G McVie
January 1989,
Bone marrow transplantation,
A D Ho, and
J Thaler, and
R Willemze, and
F Lauria, and
G Derossi, and
R Kuse, and
P Stryckmans, and
C M Blanc, and
F Cataldo, and
G McVie
April 1986,
Cancer treatment reports,
A D Ho, and
J Thaler, and
R Willemze, and
F Lauria, and
G Derossi, and
R Kuse, and
P Stryckmans, and
C M Blanc, and
F Cataldo, and
G McVie
January 1995,
Cell transplantation,
A D Ho, and
J Thaler, and
R Willemze, and
F Lauria, and
G Derossi, and
R Kuse, and
P Stryckmans, and
C M Blanc, and
F Cataldo, and
G McVie
February 2006,
Leukemia & lymphoma,
