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We studied the ocular hypotensive efficacy and safety of 0.5% levobunolol hydrochloride and 0.5% timolol maleate administered topically once daily for 3 months in 91 patients (46 in the levobunolol group and 45 in the timolol group) with primary or secondary open-angle glaucoma or ocular hypertension. In this randomized double-masked parallel clinical study, intraocular pressure (IOP) was successfully controlled in 78% of the patients who received levobunolol and 89% of those who received timolol. The overall mean decrease in IOP was 5.6 mm Hg (decrease of 23%) in the levobunolol group and 6.7 mm Hg (26%) in the timolol group, a nonsignificant difference. In both groups the overall mean IOP during treatment was significantly lower than the pretreatment value (p less than 0.001). For both treatment groups changes in heart rate and blood pressure were minimal. We conclude that both 0.5% levobunolol and 0.5% timolol administered once daily are effective and safe in lowering IOP in most patients with ocular hypertension or open-angle glaucoma.
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M Lazar, and
Y Almog, and
R P LeBlanc, and
C Mann, and
A Orr, and
P F Lee, and
B R Friedland, and
G D Novack, and
E P Kelley
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S I Rakofsky, and
M Lazar, and
Y Almog, and
R P LeBlanc, and
C Mann, and
A Orr, and
P F Lee, and
B R Friedland, and
G D Novack, and
E P Kelley
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American journal of ophthalmology,
S I Rakofsky, and
M Lazar, and
Y Almog, and
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C Mann, and
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P F Lee, and
B R Friedland, and
G D Novack, and
E P Kelley
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S I Rakofsky, and
M Lazar, and
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C Mann, and
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Ophthalmology,
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M Lazar, and
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E P Kelley
March 2002,
The AIDS reader,
S I Rakofsky, and
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E P Kelley
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Japanese journal of ophthalmology,
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January 1989,
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E P Kelley
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American journal of ophthalmology,
S I Rakofsky, and
M Lazar, and
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B R Friedland, and
G D Novack, and
E P Kelley
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Ophthalmology,
