A problem often confronting the orthodontist is that of missing upper incisors. In evaluation of the individual case, the dicision as to space closure or space regaining and eventual prosthetic reconstruction can be perplexing. Various diagnostic criteria, such as skeletal relation, arch-length analysis, inclination of teeth, and dental esthetics, must be evaluated. On the basis of this diagnostic information, treatment alternative is chosen to correct the malocclusion. The solution may be found in maintaining space, necessitating postorthodontic prosthetic replacement, or closing space and thus avoiding the need for artificial teeth. Four cases are shown to illustrate different approaches to the treatment of patients with upper incisors missing. Other solutions are possible anc correct. Each case must be weighed on its own merits.