Infantile colic is a common and frustrating condition for parents and health care practitioners. A commonly held belief is that the condition is benign and only results in transient loss of parental sleep; however, a detailed study of the recent literature and clinical studies suggests that not all colic abates without residual consequences. In this article, we outline current understanding of the condition and suggest methods of intervention. In addition, we focus on the potential effect of colic on infant attachment; the later growth and development of the once-colicky child; the evidence that supporting and refuting commonly held beliefs, and areas of intervention.