Impact of expiratory strength training in amyotrophic lateral sclerosis. 2016

Emily K Plowman, and Stephanie A Watts, and Lauren Tabor, and Raele Robison, and Joy Gaziano, and Amanda S Domer, and Joel Richter, and Tuan Vu, and Clifton Gooch
Department of Speech, Language and Hearing Sciences, University of Florida, P.O. Box 117420, Gainesville, Florida, 32610, USA.

We evaluated the feasibility and impact of expiratory muscle strength training (EMST) on respiratory and bulbar function in persons with amyotrophic lateral sclerosis (ALS). Twenty-five ALS patients participated in this delayed intervention open-label clinical trial. Following a lead-in period, patients completed a 5-week EMST protocol. Outcome measures included: maximum expiratory pressure (MEP); physiologic measures of swallow and cough; and penetration-aspiration scale (PAS) scores. Of participants who entered the active phase of the study (n = 15), EMST was well tolerated and led to significant increases in MEPs and maximum hyoid displacement during swallowing post-EMST (P < 0.05). No significant differences were observed for PAS scores or cough spirometry measures. EMST was feasible and well tolerated in this small cohort of ALS patients and led to improvements in expiratory force-generating pressures and swallow kinematics. Further investigation is warranted to confirm these preliminary findings. Muscle Nerve 54: 48-53, 2016.

UI MeSH Term Description Entries
D008297 Male Males
D008609 Mental Status Schedule Standardized clinical interview used to assess current psychopathology by scaling patient responses to the questions.
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010244 Bulbar Palsy, Progressive A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900) Fazio-Londe Disease,Fazio-Londe Syndrome,Fazio-Londe's Disease,Fazio-Londe's Syndrome,Paralysis, Bulbar,Bulbar Palsy,Bulbar Palsy, Progressive, Of Childhood,Childhood Progressive Bulbar Palsy,Progressive Bulbar Palsy of Childhood,Bulbar Palsies,Bulbar Palsies, Progressive,Bulbar Paralyses,Bulbar Paralysis,Disease, Fazio-Londe,Disease, Fazio-Londe's,Fazio Londe Disease,Fazio Londe Syndrome,Fazio Londe's Disease,Fazio Londe's Syndrome,Palsies, Bulbar,Palsies, Progressive Bulbar,Palsy, Bulbar,Palsy, Progressive Bulbar,Progressive Bulbar Palsies,Syndrome, Fazio-Londe,Syndrome, Fazio-Londe's
D012120 Respiration Disorders Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available. Disorder, Respiration,Disorders, Respiration,Respiration Disorder
D012132 Respiratory Muscles These include the muscles of the DIAPHRAGM and the INTERCOSTAL MUSCLES. Ventilatory Muscles,Respiratory Muscle,Muscle, Respiratory,Muscle, Ventilatory,Muscles, Respiratory,Muscles, Ventilatory,Ventilatory Muscle
D003371 Cough A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs. Coughs
D003679 Deglutition The act of taking solids and liquids into the GASTROINTESTINAL TRACT through the mouth and throat. Swallowing,Deglutitions,Swallowings
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Emily K Plowman, and Stephanie A Watts, and Lauren Tabor, and Raele Robison, and Joy Gaziano, and Amanda S Domer, and Joel Richter, and Tuan Vu, and Clifton Gooch
January 2019, Muscle & nerve,
Emily K Plowman, and Stephanie A Watts, and Lauren Tabor, and Raele Robison, and Joy Gaziano, and Amanda S Domer, and Joel Richter, and Tuan Vu, and Clifton Gooch
September 1998, American journal of respiratory and critical care medicine,
Emily K Plowman, and Stephanie A Watts, and Lauren Tabor, and Raele Robison, and Joy Gaziano, and Amanda S Domer, and Joel Richter, and Tuan Vu, and Clifton Gooch
May 1979, Chest,
Emily K Plowman, and Stephanie A Watts, and Lauren Tabor, and Raele Robison, and Joy Gaziano, and Amanda S Domer, and Joel Richter, and Tuan Vu, and Clifton Gooch
September 2005, Chest,
Emily K Plowman, and Stephanie A Watts, and Lauren Tabor, and Raele Robison, and Joy Gaziano, and Amanda S Domer, and Joel Richter, and Tuan Vu, and Clifton Gooch
June 2006, Revue neurologique,
Emily K Plowman, and Stephanie A Watts, and Lauren Tabor, and Raele Robison, and Joy Gaziano, and Amanda S Domer, and Joel Richter, and Tuan Vu, and Clifton Gooch
December 2008, Journal of clinical neuromuscular disease,
Emily K Plowman, and Stephanie A Watts, and Lauren Tabor, and Raele Robison, and Joy Gaziano, and Amanda S Domer, and Joel Richter, and Tuan Vu, and Clifton Gooch
January 2005, Chest,
Emily K Plowman, and Stephanie A Watts, and Lauren Tabor, and Raele Robison, and Joy Gaziano, and Amanda S Domer, and Joel Richter, and Tuan Vu, and Clifton Gooch
January 2019, Muscle & nerve,
Emily K Plowman, and Stephanie A Watts, and Lauren Tabor, and Raele Robison, and Joy Gaziano, and Amanda S Domer, and Joel Richter, and Tuan Vu, and Clifton Gooch
January 2009, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases,
Emily K Plowman, and Stephanie A Watts, and Lauren Tabor, and Raele Robison, and Joy Gaziano, and Amanda S Domer, and Joel Richter, and Tuan Vu, and Clifton Gooch
April 2023, Dysphagia,
Copied contents to your clipboard!