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Sialidase (neuraminidase; acylneuraminyl hydrolase; EC 3.2.1.18)-treated erythrocytes obtained from different species are susceptible to rapid elimination from the circulation and are sequestered in the liver and spleen. The present studies were concerned with the mechanism of this clearance and how it may relate to the normal physiological process of removing senescent erythrocytes from the circulation. The results obtained indicate a preferential recognition of sialidase-treated as compared to normal erythrocytes by mono-nuclear spleen cells and Kupffer cells of the liver. This recognition manifests itself in both autologous and homologous systems by adhesion of the complementary cells in the form of rosettes, and as such could explain the removal of enzyme-treated erythrocytes from the circulation with their accumulation in liver and spleen. This phenomenon may represent a normal physiological mechanism for removal of senescent erythrocytes containing decreased sialic acid.
D Aminoff, and
W F Bruegge, and
W C Bell, and
K Sarpolis, and
R Williams
March 1974,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
D Aminoff, and
W F Bruegge, and
W C Bell, and
K Sarpolis, and
R Williams
June 1974,
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D Aminoff, and
W F Bruegge, and
W C Bell, and
K Sarpolis, and
R Williams
March 1971,
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D Aminoff, and
W F Bruegge, and
W C Bell, and
K Sarpolis, and
R Williams
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D Aminoff, and
W F Bruegge, and
W C Bell, and
K Sarpolis, and
R Williams
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D Aminoff, and
W F Bruegge, and
W C Bell, and
K Sarpolis, and
R Williams
October 1963,
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D Aminoff, and
W F Bruegge, and
W C Bell, and
K Sarpolis, and
R Williams
January 1975,
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D Aminoff, and
W F Bruegge, and
W C Bell, and
K Sarpolis, and
R Williams
March 2010,
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D Aminoff, and
W F Bruegge, and
W C Bell, and
K Sarpolis, and
R Williams
August 1984,
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D Aminoff, and
W F Bruegge, and
W C Bell, and
K Sarpolis, and
R Williams
November 1964,
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