BIOMAT Database Logo BIOMAT Database Logo

Genotoxicity of zinc in 4 short-term mutagenicity assays. 1989

E D Thompson, and J A McDermott, and T B Zerkle, and J A Skare, and B L Evans, and D B Cody
Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45239-8707.

The genotoxicity of zinc was examined in 4 short-term mutagenicity assays. Zinc acetate produced dose-related positive responses in the L5178Y mouse lymphoma assay and an in vitro cytogenetic assay with Chinese hamster ovary cells, but was negative in the Salmonella mutation assay and did not induce unscheduled DNA synthesis in primary cultures of rat hepatocytes. Zinc-2,4-pentanedione produced frameshift mutations in Salmonella tester strains TA1538 and TA98, but did not induce unscheduled DNA synthesis in primary cultures of rat hepatocytes. The effect of ligand binding of zinc in the in vitro test systems is discussed.

UI MeSH Term Description Entries
D009152 Mutagenicity Tests Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests. Genetic Toxicity Tests,Genotoxicity Tests,Mutagen Screening,Tests, Genetic Toxicity,Toxicity Tests, Genetic,Genetic Toxicity Test,Genotoxicity Test,Mutagen Screenings,Mutagenicity Test,Screening, Mutagen,Screenings, Mutagen,Test, Genotoxicity,Tests, Genotoxicity,Toxicity Test, Genetic
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D004260 DNA Repair The removal of DNA LESIONS and/or restoration of intact DNA strands without BASE PAIR MISMATCHES, intrastrand or interstrand crosslinks, or discontinuities in the DNA sugar-phosphate backbones. DNA Damage Response
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012486 Salmonella typhimurium A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER. Salmonella typhimurium LT2
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D015032 Zinc A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D066298 In Vitro Techniques Methods to study reactions or processes taking place in an artificial environment outside the living organism. In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In

Related Publications

E D Thompson, and J A McDermott, and T B Zerkle, and J A Skare, and B L Evans, and D B Cody
Lack of genotoxicity with acrylate polymers in five short-term mutagenicity assays.
January 1989, Environmental and molecular mutagenesis,
E D Thompson, and J A McDermott, and T B Zerkle, and J A Skare, and B L Evans, and D B Cody
Evaluation of olestra in short-term genotoxicity assays.
February 1990, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
E D Thompson, and J A McDermott, and T B Zerkle, and J A Skare, and B L Evans, and D B Cody
Occupational genotoxicity assessment by mutagenicity assays.
May 1995, Toxicology letters,
E D Thompson, and J A McDermott, and T B Zerkle, and J A Skare, and B L Evans, and D B Cody
Genotoxicity Studies on Carrageenan: Short-term In Vitro Assays.
March 2009, Toxicological research,
E D Thompson, and J A McDermott, and T B Zerkle, and J A Skare, and B L Evans, and D B Cody
Mutagenicity of alkyl glycidyl ethers in three short-term assays.
November 1981, Mutation research,
E D Thompson, and J A McDermott, and T B Zerkle, and J A Skare, and B L Evans, and D B Cody
Genotoxicity of cocoa in a series of short-term assays.
March 1986, Mutation research,
E D Thompson, and J A McDermott, and T B Zerkle, and J A Skare, and B L Evans, and D B Cody
Genotoxicity of theobromine in a series of short-term assays.
March 1986, Mutation research,
E D Thompson, and J A McDermott, and T B Zerkle, and J A Skare, and B L Evans, and D B Cody
Genotoxicity of beryllium, gallium and antimony in short-term assays.
December 1991, Mutation research,
E D Thompson, and J A McDermott, and T B Zerkle, and J A Skare, and B L Evans, and D B Cody
The toxicological effects of saccharin in short-term genotoxicity assays.
September 1989, Mutation research,
E D Thompson, and J A McDermott, and T B Zerkle, and J A Skare, and B L Evans, and D B Cody
Lack of genotoxicity of cross-linked acrylate polymers in four short-term genotoxicity assays.
January 1991, Environmental and molecular mutagenesis,
Copied contents to your clipboard!