Diabetic retinopathy in Nigerians: relation to duration of diabetes, type of treatment and degree of control. 1989

R T Erasmus, and R A Alanamu, and B Bojuwoye, and P Oluboyo, and A Arije

The results of a prospective study of the prevalence of diabetic retinopathy among Nigerian diabetics attending a Nigerian Teaching Hospital over a one and a half-year period are presented. Diabetics with mature cataracts whose fundi could not be visualised were excluded from the study. 15.1% of the 377 diabetic patients included in the study group had changes consistent with diabetic retinopathy. The prevalence was found to increase with increasing duration of disease, being 12.7%, 16.8% and 20.0% in patients with duration less than 5 years, between 5 and 10 years and greater than 10 years respectively. A considerably higher prevalence was also found in the insulin treated diabetics compared to the non insulin treated group (P less than 0.05). The degree of glycaemic control appeared to be poorer in the diabetics with retinopathy compared to those without, even though the differences between the mean fasting plasma glucose concentrations between the two groups did not reach statistical significance. Proteinuria was found to be significantly commoner in diabetics with retinopathy (P less than 0.025). It was concluded that diabetic retinopathy is on the increase among Nigerians and that efforts should be directed at evolving preventive measures and early identification of high risk patients.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009549 Nigeria A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja. Federal Republic of Nigeria
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D003430 Cross-Sectional Studies Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time. Disease Frequency Surveys,Prevalence Studies,Analysis, Cross-Sectional,Cross Sectional Analysis,Cross-Sectional Survey,Surveys, Disease Frequency,Analyses, Cross Sectional,Analyses, Cross-Sectional,Analysis, Cross Sectional,Cross Sectional Analyses,Cross Sectional Studies,Cross Sectional Survey,Cross-Sectional Analyses,Cross-Sectional Analysis,Cross-Sectional Study,Cross-Sectional Surveys,Disease Frequency Survey,Prevalence Study,Studies, Cross-Sectional,Studies, Prevalence,Study, Cross-Sectional,Study, Prevalence,Survey, Cross-Sectional,Survey, Disease Frequency,Surveys, Cross-Sectional
D003920 Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
D003930 Diabetic Retinopathy Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION. Diabetic Retinopathies,Retinopathies, Diabetic,Retinopathy, Diabetic
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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