We studied 151 patients aged from 49 to 85 years (mean 71) with a clinical suspect of prostatic cancer. 104 underwent a transrectal digitally directed prostatic biopsy, while 47 an ultrasonically perineal guided prostatic biopsy. Transrectal fine needle aspiration was performed in the whole group. Both techniques showed a high cyto-histologic concordance: 83.6% with transrectal digitally directed biopsy, 78.7% with perineal ultrasonically guided biopsy. The ultrasound guided biopsy has been able to downset the rate of cytologic false negatives in comparison to the digitally guided biopsy. In case of pathological rectal examination, digitally directed prostatic biopsy is still available and those who haven't an ultrasound apparatus, can equally perform a traditional biopsy with a limited possibility of mistake.