Biomaterial Database

[Ethylene glycol and propylene glycol ethers - Reproductive and developmental toxicity]. 2015

Beata Starek-Świechowicz, and Andrzej Starek

Collegium Medicum Uniwersytetu Jagiellońskiego / Jagiellonian University Medical College, Kraków, Poland (Wydział Farmaceutyczny, Zakład Biochemii Toksykologicznej / Faculty of Pharmacy, Department of Biochemical Toxicology). beata.starek@gmail.com.

Both ethylene and propylene glycol alkyl ethers (EGAEs and PGAEs, respectively) are widely used, mainly as solvents, in industrial and household products. Some EGAEs demonstrate gonadotoxic, embriotoxic, fetotoxic and teratogenic effects in both humans and experimental animals. Due to the noxious impact of these ethers on reproduction and development of organisms EGAEs are replaced for considerably less toxic PGAEs. The data on the mechanisms of testicular, embriotoxic, fetotoxic and teratogenic effects of EGAEs are presented in this paper. Our particular attention was focused on the metabolism of some EGAEs and their organ-specific toxicities, apoptosis of spermatocytes associated with changes in the expression of various genes that code for oxidative stress factors, protein kinases and nuclear hormone receptors.

UI	MeSH Term	Description	Entries
D004987	Ethers	Organic compounds having two alkyl or aryl groups bonded to an oxygen atom, as in the formula R1–O–R2.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006803	Human Development	Continuous sequential changes which occur in the physiological and psychological functions during the life-time of an individual.	Development, Human
D012997	Solvents	Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)	Solvent
D055703	Reproductive Physiological Phenomena	Physiological processes, factors, properties and characteristics pertaining to REPRODUCTION.	Reproductive Physiological Concepts,Reproductive Physiological Processes,Reproductive Physiologic Concepts,Reproductive Physiological Phenomenon,Reproductive Physiological Process,Concept, Reproductive Physiologic,Concept, Reproductive Physiological,Concepts, Reproductive Physiologic,Concepts, Reproductive Physiological,Phenomena, Reproductive Physiological,Phenomenon, Reproductive Physiological,Physiologic Concept, Reproductive,Physiologic Concepts, Reproductive,Physiological Concept, Reproductive,Physiological Process, Reproductive,Physiological Processes, Reproductive,Process, Reproductive Physiological,Processes, Reproductive Physiological,Reproductive Physiologic Concept,Reproductive Physiological Concept
D019855	Ethylene Glycol	A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.	1,2-Ethanediol,2-Hydroxyethanol,Monoethylene Glycol,1,2 Ethanediol,2 Hydroxyethanol,Glycol, Ethylene,Glycol, Monoethylene
D019946	Propylene Glycol	A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.	1,2-Propanediol,Propan-1,2-Diol,Propylene Glycol Monohydrate,Propylene Glycol Sodium Salt,Propylene Glycol, (+-)-Isomer,Propylene Glycol, (R)-Isomer,Propylene Glycol, (S)-Isomer,1,2 Propanediol,Glycol, Propylene,Monohydrate, Propylene Glycol