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Results of cellular and genetic characterization of UV sensitive clones (UVs) isolated from CHO-K1 cell line are reported. The cross-sensitivity to agents inducing a variety of DNA lesions, the induction of chromosome aberrations and of 6-thioguanine and ouabain resistant mutants, the occurrence of methotrexate resistant cells were analyzed in clones showing different degrees of UV sensitivity. Genetic analysis was performed by complementation analysis of hybrids obtained by fusion of our mutants with UVs cells belonging to the six complementation groups (c.g.) so far identified. Three clones were assigned to c.g. 2, one clone to c.g. 5. Two clones (CHO7PV and CHO4PV), were able to complement each other and showed complementation after fusion with any of the six c.g.; these clones were considered carriers of two new mutations in genes presumably involved in DNA repair.
M Stefanini, and
C Mondello, and
E Botta, and
R Riboni, and
F Nuzzo
June 1981,
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Somatic cell genetics,
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January 1996,
Mutagenesis,
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March 1991,
Mutation research,
M Stefanini, and
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January 1973,
Mutation research,
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September 1988,
Mutation research,
M Stefanini, and
C Mondello, and
E Botta, and
R Riboni, and
F Nuzzo
March 1981,
Somatic cell genetics,
M Stefanini, and
C Mondello, and
E Botta, and
R Riboni, and
F Nuzzo
January 1988,
Mutation research,
M Stefanini, and
C Mondello, and
E Botta, and
R Riboni, and
F Nuzzo
November 1986,
Mutation research,
