Biomaterial Database

[Clinical application of anti-idiotypic antibody]. 1989

A Yachi, and M Tsujisaki, and K Imai

Dept. of Internal Medicine, Sapporo Medical College.

The concept of idiotype networks are supposed to play important roles in regulation of the immune response, and anti-idiotypic (anti-Id) antibodies have enabled to analyze the pathogenesis of autoimmune diseases and structural relations of receptors and ligands in clinical fields. We applied anti-idiotypic monoclonal antibodies (MoAb) to tumor immunology to analyze idiotype network system of tumor associated antigen (TAA) and to investigate the fine structure of TAAs and their corresponding antibodies. New assays were established to detect circulating TAAs, anti-TAA antibodies and their immune complex regarding YH 206 antigen and carcinoembryonic antigen (CEA) systems. The measurement of anti-TAA antibodies and immune complex was found to be of value for the cancer diagnosis. The results about immune response with use of anti-Id monoclonal antibodies suggest that some of the anti-Id antibodies might be useful for cancer therapy, since anti-Id antibody could induce anti-anti-Id antibodies reactive with tumor antigen. In this review, the usefulness of anti-Id MoAb to serodiagnosis and immunotherapy for cancer was discussed.

UI	MeSH Term	Description	Entries
D007130	Immunoglobulin Idiotypes	Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.	Idiotypes, Immunoglobulin,Ig Idiotypes,Idiotype, Ig,Idiotype, Immunoglobulin,Idiotypes, Ig,Ig Idiotype,Immunoglobulin Idiotype
D009369	Neoplasms	New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D002272	Carcinoembryonic Antigen	A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.	Antigens, CD66e,CD66e Antigen,Antigen, CD66e,Antigen, Carcinoembryonic,CD66e Antigens
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000911	Antibodies, Monoclonal	Antibodies produced by a single clone of cells.	Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D001323	Autoantibodies	Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.	Autoantibody