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Rheumatoid synovial tissue and noninflammatory synovial tissue from patients with meniscus lesions were stained using monoclonal antibodies against platelet 150 kDa Ib glycoprotein (gp Ib) and against 140/110 kDa IIb-IIIa glycoprotein complex (gp IIb-IIIa) applied with the avidin-biotin-peroxidase complex method. Gp Ib and gp IIb-IIIa positive intravascular platelet aggregates were not seen, except locally in the capillary blood vessels of one rheumatoid synovial sample. This suggests that the platelets and the clotting sequence are not activated in inflamed synovial tissue. However, in many of the synovial capillaries endothelial immunoreactivity was seen. This reaction could have been due to cross reaction, since the vitronectin receptor beta chain is structurally identical to platelet gp IIIa. The gp IIb-IIIa member of the integrin receptor family plays a role in the transmembrane linkage between its extracellular ligands and intracellular microfibers. Gp IIb-IIIa may thus contribute to normal synovial physiology and to the pathogenesis of chronic synovitis.
Y T Konttinen, and
M Grönblad, and
V Bergroth, and
S Santavirta, and
I Antti-Poika
June 1997,
Blood,
Y T Konttinen, and
M Grönblad, and
V Bergroth, and
S Santavirta, and
I Antti-Poika
November 1988,
Blood,
Y T Konttinen, and
M Grönblad, and
V Bergroth, and
S Santavirta, and
I Antti-Poika
February 1991,
Blood,
Y T Konttinen, and
M Grönblad, and
V Bergroth, and
S Santavirta, and
I Antti-Poika
November 1987,
Blood,
Y T Konttinen, and
M Grönblad, and
V Bergroth, and
S Santavirta, and
I Antti-Poika
January 1997,
Nephron,
Y T Konttinen, and
M Grönblad, and
V Bergroth, and
S Santavirta, and
I Antti-Poika
October 1992,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
Y T Konttinen, and
M Grönblad, and
V Bergroth, and
S Santavirta, and
I Antti-Poika
February 1987,
Blood,
Y T Konttinen, and
M Grönblad, and
V Bergroth, and
S Santavirta, and
I Antti-Poika
August 1986,
British journal of haematology,
Y T Konttinen, and
M Grönblad, and
V Bergroth, and
S Santavirta, and
I Antti-Poika
December 1987,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
Y T Konttinen, and
M Grönblad, and
V Bergroth, and
S Santavirta, and
I Antti-Poika
September 1992,
British journal of haematology,
