Biomaterial Database

Prevention of the immediate intraocular pressure rise following argon laser trabeculoplasty. 1989

T W Metcalfe, and D E Etchells

Department of Ophthalmology, Bradford Royal Infirmary.

A prospective, randomised double-masked study was undertaken to compare the effect of pretreatment with acetazolamide or placebo on the immediate intraocular pressure (IOP) rise following argon laser trabeculoplasty. One hundred eyes (100 patients) underwent 180 degree of laser treatment with a mean of 59 spots of 50 microns size and 800 to 1000 mW power. The IOP was measured during the first three hours after laser treatment, at 24 hours, and at two months. Forty-six patients (92%) in the placebo group had an immediate rise of IOP. The mean rise (SD) for these patients was 8.6 (7.1) mmHg. Fifteen patients (30%) in this group had an IOP rise of greater than 10 mmHg. Nine patients (18%) receiving acetazolamide had an immediate rise of IOP. The mean rise for these patients was 4.3 (3.1) mmHg, and no patient had an increase in IOP of greater than 8 mmHg. Acetazolamide appears to be effective in preventing a critical IOP rise after argon laser trabeculoplasty (p less than 0.0001).

UI	MeSH Term	Description	Entries
D007429	Intraocular Pressure	The pressure of the fluids in the eye.	Ocular Tension,Intraocular Pressures,Ocular Tensions,Pressure, Intraocular,Pressures, Intraocular,Tension, Ocular,Tensions, Ocular
D008297	Male		Males
D011183	Postoperative Complications	Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D011292	Premedication	Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.	Premedications
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D004311	Double-Blind Method	A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.	Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man