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Intercellular adhesion molecule-1 (ICAM-1), hitherto identified on activated B cells, macrophages, dendritic cells, endothelia and certain epithelial cells, serves as a ligand for the lymphocyte function-associated antigen-1 (LFA-1). ICAM-1 binding by LFA-1 enhances the efficiency of lymphocyte-target cell and lymphocyte-accessory cell interactions. We have investigated the in-vitro expression of ICAM-1 by cultured thyroid cells from five patients with Graves' disease using indirect immunofluorescence analysis, and found that 30 +/- 11% (mean +/- S.D.) of cells were ICAM-1 positive under basal conditions. The proportion of cells which were ICAM-1 positive and the amount of ICAM-1 per cell (assessed by fluorescence intensity) were both increased in all cases by the cytokines gamma-interferon, interleukin-1 and tumour necrosis factor. Immunohistochemical analysis of frozen sections from thyroidectomy specimens demonstrated ICAM-1 on thyroid follicular cells in areas of lymphocytic infiltration in patients with Graves' disease (n = 2) or Hashimoto's thyroiditis (n = 2). ICAM-1 was not found in specimens from a patient with a toxic multinodular goitre or a patient with Graves' disease without focal lymphocytic accumulation. These results suggest that the thyroid epithelium may express ICAM-1 as well as major histocompatibility complex class II antigens, such as HLA-DR, in response to locally synthesized cytokines. The enhanced expression of ICAM-1 may render these cells more susceptible as targets for lymphocyte-mediated cytotoxicity, and together with HLA-DR antigen expression may increase the accessory cell capability of the thyroid follicular cells.
A P Weetman, and
S Cohen, and
M W Makgoba, and
L K Borysiewicz
August 1992,
Immunobiology,
A P Weetman, and
S Cohen, and
M W Makgoba, and
L K Borysiewicz
July 1990,
Clinical and experimental immunology,
A P Weetman, and
S Cohen, and
M W Makgoba, and
L K Borysiewicz
January 1994,
The Kurume medical journal,
A P Weetman, and
S Cohen, and
M W Makgoba, and
L K Borysiewicz
January 1995,
Annales pharmaceutiques francaises,
A P Weetman, and
S Cohen, and
M W Makgoba, and
L K Borysiewicz
May 1990,
Molecular and cellular endocrinology,
A P Weetman, and
S Cohen, and
M W Makgoba, and
L K Borysiewicz
May 1993,
Cellular immunology,
A P Weetman, and
S Cohen, and
M W Makgoba, and
L K Borysiewicz
November 1993,
Gut,
A P Weetman, and
S Cohen, and
M W Makgoba, and
L K Borysiewicz
January 1991,
Connective tissue research,
A P Weetman, and
S Cohen, and
M W Makgoba, and
L K Borysiewicz
January 1993,
Pathologica,
A P Weetman, and
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M W Makgoba, and
L K Borysiewicz
March 1999,
Infection and immunity,
