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Synthesis and Herbicidal Activity of 5-Heterocycloxy-3-methyl-1-substituted-1H-pyrazoles. 2015

Jing Kang, and Xia Li Yue, and Chang Shui Chen, and Jian Hong Li, and Hong Ju Ma
Department of Applied Chemistry, College of Science, Huazhong Agricultural University, Wuhan 430070, China. kangjing@webmail.hzau.edu.cn.

With the objective of finding valuable herbicidal candidates, a series of new 5-heterocycloxy-3-methyl-1-substituted-1H-pyrazoles were synthesized and their herbicidal activities were evaluated. The bioassay results showed that some compounds exhibited excellent herbicidal activities at the concentration of 100 mg/L, and compound 5-chloro-2-((3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)oxy)pyrimidine showed bleaching activity to green weeds. In greenhouse conditions, this compound also showed excellent post-emergence herbicidal effect against Digitaria sanguinalis L. at the dosage of 750 g a. i. ha(-1).

UI MeSH Term Description Entries
D011720 Pyrazoles Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.
D006540 Herbicides Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE. Algaecide,Algicide,Herbicide,Algaecides,Algicides
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D057685 Plant Weeds A plant growing in a location where it is not wanted, often competing with cultivated plants. Annual Weeds,Invasive Weeds,Noxious Weeds,Parasitic Weeds,Perennial Weeds,Annual Weed,Invasive Weed,Noxious Weed,Parasitic Weed,Perennial Weed,Plant Weed,Weed, Annual,Weed, Invasive,Weed, Noxious,Weed, Parasitic,Weed, Perennial,Weed, Plant,Weeds, Annual,Weeds, Invasive,Weeds, Noxious,Weeds, Parasitic,Weeds, Perennial,Weeds, Plant

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