BACKGROUND Cat scratch disease is an infection caused by Bartonella henselae. The main clinical form is a lymphadenopathy with fever. However, uncommon bone involvement has been described. METHODS In this paper, we report a case of osteomyelitis in a 13-year-old teenager infected with B. henselae. The diagnosis was made based on PCR only because the serology was negative. A literature review reports 65 cases of osteomyelitis due to cat scratch disease. For each case, serology and PCR were notified. CONCLUSIONS Osteomyelitis caused by B. henselae is a rare clinical manifestation. The diagnosis can be difficult, but the medical history must be accurate to search for contact with a cat and a cat scratch.