-transparent.png){kind=logo}
Understanding of the roles and molecular mechanisms of hematopoietic growth factors has increased greatly in recent years. This past decade has also brought us tantalizingly close to linking a group of genes normally involved in the regulation of growth and differentiation--the cellular proto-oncogenes--to the process of malignant transformation. In this article, we review the known actions of hematopoietic growth factors in normal hematopoiesis and in hematologic malignancies. We then discuss current concepts of the roles of proto-oncogenes in normal cells and their potential involvement in leukemogenic events. A merging of these concepts with classical hypotheses of multistage carcinogenesis is emphasized.
M B Kastan, and
L C Strauss, and
C I Civin
December 1989,
Biochimica et biophysica acta,
M B Kastan, and
L C Strauss, and
C I Civin
August 1990,
Hematology/oncology clinics of North America,
M B Kastan, and
L C Strauss, and
C I Civin
March 1986,
Mutagenesis,
M B Kastan, and
L C Strauss, and
C I Civin
January 1992,
Cancer treatment and research,
M B Kastan, and
L C Strauss, and
C I Civin
January 1992,
Pigment cell research,
M B Kastan, and
L C Strauss, and
C I Civin
January 2021,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
M B Kastan, and
L C Strauss, and
C I Civin
April 1989,
Trends in pharmacological sciences,
M B Kastan, and
L C Strauss, and
C I Civin
May 1988,
Mutation research,
M B Kastan, and
L C Strauss, and
C I Civin
January 1989,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
M B Kastan, and
L C Strauss, and
C I Civin
March 1985,
Immunology today,
