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The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii. 2016
Shawn R Lockhart, and
Annette W Fothergill, and
Naureen Iqbal, and
Carol B Bolden, and
Nina T Grossman, and
Edward P Garvey, and
Stephen R Brand, and
William J Hoekstra, and
Robert J Schotzinger, and
Elizabeth Ottinger, and
Thomas F Patterson, and
Nathan P Wiederhold
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Thein vitroactivities of the novel fungal Cyp51 inhibitor VT-1129 were evaluated against a large panel ofCryptococcus neoformansandCryptococcus gattiiisolates. VT-1129 demonstrated potent activities against bothCryptococcusspecies as demonstrated by low MIC50and MIC90values. ForC. gattii, thein vitropotency was maintained against all genotypes. In addition, significantly lower geometric mean MICs were observed for VT-1129 than for fluconazole againstC. neoformans, including isolates with reduced fluconazole susceptibility.
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