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Clonidine (Catapres) administered intramuscularly in a dose of 150 microng produced a satisfactory reduction in blood pressure in 13 of 16 hypertensive patients. Its effect occurred within five minutes, was maximal at 75 minutes and persisted for five hours. In six patients who received two doses (150 microng and 300 microng), the response was shown to be dose-related. No serious side effects were noted. Intramuscular administration of clonidine thus appears to be safe and effective. It has a place in the management of uncontrolled hypertension when a rapid reduction in blood pressure is undesirable and in the maintenance of blood pressure control when oral therapy cannot be tolerated.
R M Graham, and
J M Gain, and
G S Stokes
November 1971,
The Medical journal of Australia,
R M Graham, and
J M Gain, and
G S Stokes
September 1971,
Lyon medical,
R M Graham, and
J M Gain, and
G S Stokes
July 1983,
Casopis lekaru ceskych,
R M Graham, and
J M Gain, and
G S Stokes
February 1976,
Annals of clinical research,
R M Graham, and
J M Gain, and
G S Stokes
May 1903,
British medical journal,
R M Graham, and
J M Gain, and
G S Stokes
January 1980,
Journal of cardiovascular pharmacology,
R M Graham, and
J M Gain, and
G S Stokes
September 1976,
The Journal of the Association of Physicians of India,
R M Graham, and
J M Gain, and
G S Stokes
January 1977,
Harefuah,
R M Graham, and
J M Gain, and
G S Stokes
February 1971,
British medical journal,
R M Graham, and
J M Gain, and
G S Stokes
January 1971,
British medical journal,
