[Study on virulence factors of Candida tropicalis isolated from clinical samples]. 2015

Shuanbao Yu, and Wenge Li, and Jie Che, and Funing Bian, and Jinxing Lu, and Yuan Wu
State Key Laboratory for Communicable Diseases Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

OBJECTIVE To determine the in vitro production of virulence factors for Candida (C.) tropicalis, including aspartyl proteinases, phospholipases and hemolytic activities, describe the regulation of virulence factors varying with time in C. tropicalis, and analyze the differences in aspartyl proteinases and hemolytic activities of C. tropicalis isolated from anatomically distinct sites. METHODS A total of 64 C. tropicalis strains were spot-inoculated onto bovine albumin agar, egg yolk agar and sheep blood agar plates, respectively. Then the plates were incubated for 24, 48 and 72 hour at 37 °C, respectively. The aspartyl proteinases, phospholipase and hemolytic activities were determined at each time point, respectively. RESULTS All the C. tropiclais isolates showed positive aspartyl proteinases and hemolytic activities at each time point, but no phospholipases activity was detected in C. tropicalis. On comparison of aspartyl proteinases and hemolytic activities at different time points, aspartyl proteinases activity at 48 and 72 hour was higher than that at 24 hour. During 72 hour, hemolytic activity of C. tropicalis increased. No statistical significant differences in aspartyl proteinases and hemolytic activities of C. tropicalis were observed among different infection sites (P=0.368 and 0.985). CONCLUSIONS The C. tropicalis clinical isolates in China have aspartyl proteinases activity, hemolytic activity, but have no phospholipase activity.

UI MeSH Term Description Entries
D010740 Phospholipases A class of enzymes that catalyze the hydrolysis of phosphoglycerides or glycerophosphatidates. EC 3.1.-. Lecithinases,Lecithinase,Phospholipase
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D002681 China A country spanning from central Asia to the Pacific Ocean. Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D003470 Culture Media Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN. Media, Culture
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001426 Bacterial Proteins Proteins found in any species of bacterium. Bacterial Gene Products,Bacterial Gene Proteins,Gene Products, Bacterial,Bacterial Gene Product,Bacterial Gene Protein,Bacterial Protein,Gene Product, Bacterial,Gene Protein, Bacterial,Gene Proteins, Bacterial,Protein, Bacterial,Proteins, Bacterial
D012756 Sheep Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS. Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D057055 Aspartic Acid Proteases A subclass of peptide hydrolases that depend on an ASPARTIC ACID residue for their activity. Aspartic Acid Protease,Aspartic Acid Proteinase,Aspartic Acid Proteinases,Aspartic Proteinase,Aspartic Proteinases,Aspartyl Protease,Aspartyl Proteinase,Aspartyl Proteinases,Aspartyl Proteases,Acid Protease, Aspartic,Acid Proteases, Aspartic,Acid Proteinase, Aspartic,Protease, Aspartic Acid,Protease, Aspartyl,Proteases, Aspartic Acid,Proteases, Aspartyl,Proteinase, Aspartic,Proteinase, Aspartic Acid,Proteinase, Aspartyl,Proteinases, Aspartic,Proteinases, Aspartic Acid,Proteinases, Aspartyl
D037521 Virulence Factors Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486) Pathogenicity Factor,Pathogenicity Factors,Virulence Factor,Factor, Pathogenicity,Factor, Virulence,Factors, Pathogenicity,Factors, Virulence

Related Publications

Shuanbao Yu, and Wenge Li, and Jie Che, and Funing Bian, and Jinxing Lu, and Yuan Wu
December 2021, Mycopathologia,
Shuanbao Yu, and Wenge Li, and Jie Che, and Funing Bian, and Jinxing Lu, and Yuan Wu
March 2010, Mycopathologia,
Shuanbao Yu, and Wenge Li, and Jie Che, and Funing Bian, and Jinxing Lu, and Yuan Wu
January 2010, Revista da Sociedade Brasileira de Medicina Tropical,
Shuanbao Yu, and Wenge Li, and Jie Che, and Funing Bian, and Jinxing Lu, and Yuan Wu
April 2014, Medical mycology,
Shuanbao Yu, and Wenge Li, and Jie Che, and Funing Bian, and Jinxing Lu, and Yuan Wu
May 2023, Diagnostic microbiology and infectious disease,
Shuanbao Yu, and Wenge Li, and Jie Che, and Funing Bian, and Jinxing Lu, and Yuan Wu
June 2021, Nigerian journal of clinical practice,
Shuanbao Yu, and Wenge Li, and Jie Che, and Funing Bian, and Jinxing Lu, and Yuan Wu
July 2012, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
Shuanbao Yu, and Wenge Li, and Jie Che, and Funing Bian, and Jinxing Lu, and Yuan Wu
July 2010, The Journal of hospital infection,
Shuanbao Yu, and Wenge Li, and Jie Che, and Funing Bian, and Jinxing Lu, and Yuan Wu
August 1982, Infection and immunity,
Shuanbao Yu, and Wenge Li, and Jie Che, and Funing Bian, and Jinxing Lu, and Yuan Wu
July 2013, Medical mycology,
Copied contents to your clipboard!