BIOMAT Database Logo BIOMAT Database Logo

Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. A double-blind crossover comparison. 1989

H L Leonard, and S E Swedo, and J L Rapoport, and E V Koby, and M C Lenane, and D L Cheslow, and S D Hamburger
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Md 20892.

Forty-eight children and adolescents with severe primary obsessive-compulsive disorder completed a 10-week double-blind crossover trial of clomipramine hydrochloride (mean dose [+/- SD], 150 +/- 53 mg/d) and desipramine hydrochloride (mean dose [+/- SD], 153 +/- 55 mg/d). Clomipramine was clearly superior to desipramine in significantly reducing obsessive-compulsive symptoms. Age at onset, duration and severity of illness, type of symptom, and plasma drug concentrations did not predict clinical response to clomipramine. Sixty-four percent of patients who received clomipramine as their first active treatment showed at least some sign of relapse during desipramine treatment. We further document the specificity of the antiobsessional effect of clomipramine and the need for maintenance treatment.

UI MeSH Term Description Entries
D008297 Male Males
D009771 Obsessive-Compulsive Disorder An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension. Anankastic Personality,Neurosis, Obsessive-Compulsive,Anankastic Personalities,Disorder, Obsessive-Compulsive,Disorders, Obsessive-Compulsive,Neuroses, Obsessive-Compulsive,Neurosis, Obsessive Compulsive,Obsessive Compulsive Disorder,Obsessive-Compulsive Disorders,Obsessive-Compulsive Neuroses,Obsessive-Compulsive Neurosis,Personalities, Anankastic,Personality, Anankastic
D010919 Placebos Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol. Sham Treatment
D011569 Psychiatric Status Rating Scales Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness. Factor Construct Rating Scales (FCRS),Katz Adjustment Scales,Lorr's Inpatient Multidimensional Psychiatric Rating Scale,Wittenborn Scales,Edinburgh Postnatal Depression Scale,Mini International Neuropsychiatric Interview
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002986 Clinical Trials as Topic Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. Clinical Trial as Topic
D002997 Clomipramine A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine. Chlorimipramine,Anafranil,Chlomipramine,Clomipramine Hydrochloride,Clomipramine Maleate (1:1),Clomipramine Monohydrochloride,Hydiphen,Hydrochloride, Clomipramine,Monohydrochloride, Clomipramine
D003891 Desipramine A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors. Desmethylimipramine,Apo-Desipramine,Demethylimipramine,Desipramine Hydrochloride,Norpramin,Novo-Desipramine,Nu-Desipramine,PMS-Desipramine,Pertofran,Pertofrane,Pertrofran,Petylyl,Ratio-Desipramine,Apo Desipramine,Hydrochloride, Desipramine,Novo Desipramine,Nu Desipramine,PMS Desipramine,Ratio Desipramine
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked

Related Publications

H L Leonard, and S E Swedo, and J L Rapoport, and E V Koby, and M C Lenane, and D L Cheslow, and S D Hamburger
A double-blind crossover comparison of clomipramine and desipramine in the treatment of panic disorder.
March 1999, European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
H L Leonard, and S E Swedo, and J L Rapoport, and E V Koby, and M C Lenane, and D L Cheslow, and S D Hamburger
Fluvoxamine versus clomipramine for obsessive-compulsive disorder: a double-blind comparison.
April 1996, Journal of clinical psychopharmacology,
H L Leonard, and S E Swedo, and J L Rapoport, and E V Koby, and M C Lenane, and D L Cheslow, and S D Hamburger
A double-blind comparison of sertraline and clomipramine in outpatients with obsessive-compulsive disorder.
January 1997, European psychiatry : the journal of the Association of European Psychiatrists,
H L Leonard, and S E Swedo, and J L Rapoport, and E V Koby, and M C Lenane, and D L Cheslow, and S D Hamburger
Paraphilias: a double-blind crossover comparison of clomipramine versus desipramine.
December 1992, Archives of sexual behavior,
H L Leonard, and S E Swedo, and J L Rapoport, and E V Koby, and M C Lenane, and D L Cheslow, and S D Hamburger
Double-blind comparison of fluoxetine versus clomipramine in the treatment of obsessive compulsive disorder.
May 1996, European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
H L Leonard, and S E Swedo, and J L Rapoport, and E V Koby, and M C Lenane, and D L Cheslow, and S D Hamburger
Multicentre, double-blind, comparison of fluvoxamine and clomipramine in the treatment of obsessive-compulsive disorder.
March 2000, International clinical psychopharmacology,
H L Leonard, and S E Swedo, and J L Rapoport, and E V Koby, and M C Lenane, and D L Cheslow, and S D Hamburger
Double-blind, crossover trial of fluoxetine and placebo in children and adolescents with obsessive-compulsive disorder.
November 1992, Journal of the American Academy of Child and Adolescent Psychiatry,
H L Leonard, and S E Swedo, and J L Rapoport, and E V Koby, and M C Lenane, and D L Cheslow, and S D Hamburger
Clomipramine treatment of childhood obsessive-compulsive disorder. A double-blind controlled study.
October 1985, Archives of general psychiatry,
H L Leonard, and S E Swedo, and J L Rapoport, and E V Koby, and M C Lenane, and D L Cheslow, and S D Hamburger
Obsessive-compulsive disorder. A double-blind trial of clomipramine and clorgyline.
June 1983, Archives of general psychiatry,
H L Leonard, and S E Swedo, and J L Rapoport, and E V Koby, and M C Lenane, and D L Cheslow, and S D Hamburger
A double-blind study of fluvoxamine and clomipramine in the treatment of obsessive-compulsive disorder.
May 1997, International clinical psychopharmacology,
Copied contents to your clipboard!