BIOMAT Database Logo BIOMAT Database Logo

Efficacy of sulbactam/cefoperazone for the treatment of infections in patients with hematologic diseases. 1989

A Horiuchi, and H Hasegawa, and T Kageyama, and T Yonezawa, and T Kitani, and T Masaoka, and K Yasunaga, and H Kawagoe, and K Nagai
Hanshin Study Group of Hematopoietic Disorders and Infections, Japan.

The efficacy and safety of sulbactam/cefoperazone (SBT/CPZ) was studied in 94 patients with severe infections and concomitant hematologic diseases. All of the study patients were included in the evaluation for safety, and 76 cases were evaluable for efficacy. Clinical efficacy was excellent in 13 cases (17.1%), good in 27 cases (35.5%), fair in seven cases (9.2%), and poor in 29 cases (38.2%). The bacteriologic eradication was 66.7% for Gram-negative bacilli and 50.0% for Gram-positive bacteria. The efficacy rate for neutropenic patients with counts less than 50 mm3 and 100 mm3 were 47.5 and 42.9%, respectively. Efficacy in patients for whom other antibiotic therapy before treatment with SBT/CPZ had been ineffective was 46.2%. Side effects were reported in one case (1.1%), and abnormal serum liver tests in five cases (5.3%); both returned to normal after discontinuation of the study medication. SBT/CPZ was an effective antibiotic for the treatment of severe infections in the presence of concurrent hematologic diseases.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002438 Cefoperazone Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It may be used to treat Pseudomonas infections. Cefobid,Cefoperazon,Cefoperazone Sodium,Cefoperazone Sodium Salt,Céfobis,T-1551,T1551,Salt, Cefoperazone Sodium,Sodium Salt, Cefoperazone,Sodium, Cefoperazone,T 1551
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260 Female Females
D006090 Gram-Negative Bacteria Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method. Gram Negative Bacteria
D006094 Gram-Positive Bacteria Bacteria which retain the crystal violet stain when treated by Gram's method. Gram Positive Bacteria
D006402 Hematologic Diseases Disorders of the blood and blood forming tissues. Blood Diseases,Hematological Diseases,Blood Disease,Disease, Blood,Disease, Hematologic,Disease, Hematological,Diseases, Blood,Diseases, Hematologic,Diseases, Hematological,Hematologic Disease,Hematological Disease
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

A Horiuchi, and H Hasegawa, and T Kageyama, and T Yonezawa, and T Kitani, and T Masaoka, and K Yasunaga, and H Kawagoe, and K Nagai
[Clinical efficacy of sulbactam/cefoperazone for the treatment of geriatric patients with respiratory tract infections].
July 1995, The Japanese journal of antibiotics,
A Horiuchi, and H Hasegawa, and T Kageyama, and T Yonezawa, and T Kitani, and T Masaoka, and K Yasunaga, and H Kawagoe, and K Nagai
[Efficacy of sulbactam/cefoperazone in respiratory tract infections in elderly patients with underlying respiratory diseases].
July 1996, The Japanese journal of antibiotics,
A Horiuchi, and H Hasegawa, and T Kageyama, and T Yonezawa, and T Kitani, and T Masaoka, and K Yasunaga, and H Kawagoe, and K Nagai
[Clinical evaluation of sulbactam/cefoperazone for infections during the chemotherapy of hematologic malignancy].
September 1994, The Japanese journal of antibiotics,
A Horiuchi, and H Hasegawa, and T Kageyama, and T Yonezawa, and T Kitani, and T Masaoka, and K Yasunaga, and H Kawagoe, and K Nagai
[Treatment with sulbactam/cefoperazone of severe infections in patients with hematological disorders].
August 1989, The Japanese journal of antibiotics,
A Horiuchi, and H Hasegawa, and T Kageyama, and T Yonezawa, and T Kitani, and T Masaoka, and K Yasunaga, and H Kawagoe, and K Nagai
[Efficacy and safety of sulbactam/cefoperazone for hepato-biliary infections].
November 1997, The Japanese journal of antibiotics,
A Horiuchi, and H Hasegawa, and T Kageyama, and T Yonezawa, and T Kitani, and T Masaoka, and K Yasunaga, and H Kawagoe, and K Nagai
[Clinical evaluation of sulbactam/cefoperazone for lower respiratory tract infections. Correlation between the efficacy of sulbactam/cefoperazone and beta-lactamase].
August 1996, The Japanese journal of antibiotics,
A Horiuchi, and H Hasegawa, and T Kageyama, and T Yonezawa, and T Kitani, and T Masaoka, and K Yasunaga, and H Kawagoe, and K Nagai
Efficacy of Cefoperazone Sulbactam in Patients with Acinetobacter Infections: A Systematic Review of the Literature.
March 2023, Antibiotics (Basel, Switzerland),
A Horiuchi, and H Hasegawa, and T Kageyama, and T Yonezawa, and T Kitani, and T Masaoka, and K Yasunaga, and H Kawagoe, and K Nagai
[A combined sulbactam/cefoperazone and amikacin therapy for the treatment of infections complicated with hematological diseases].
March 1993, The Japanese journal of antibiotics,
A Horiuchi, and H Hasegawa, and T Kageyama, and T Yonezawa, and T Kitani, and T Masaoka, and K Yasunaga, and H Kawagoe, and K Nagai
Efficacy and safety of generic cefoperazone/sulbactam versus branded cefoperazone/sulbactam in the treatment of bacterial infections: a systematic review and meta-analysis.
April 2024, Journal of chemotherapy (Florence, Italy),
A Horiuchi, and H Hasegawa, and T Kageyama, and T Yonezawa, and T Kitani, and T Masaoka, and K Yasunaga, and H Kawagoe, and K Nagai
[Use of a combination of cefoperazone with sulbactam for treatment of patients with wound infections].
December 1994, Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
Copied contents to your clipboard!