BIOMAT Database Logo BIOMAT Database Logo

Metformin prevents cerebellar granule neurons against glutamate-induced neurotoxicity. 2016

Changwei Zhou, and Rong Sun, and Sujuan Zhuang, and Chongyi Sun, and Yongqing Jiang, and Yang Cui, and Shitou Li, and Yanqiu Xiao, and Yansheng Du, and Huiying Gu, and Qingpeng Liu
Department of Orthopedic Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China.

Metformin, a wildly used drug for type 2 diabetes, has recently been proven to protect a variety of cells from stress including stroke. Glutamate is an excitatory neurotransmitter that contributes to excitatory neuronal damage involved in stroke and neurodegenerative disorders. In this study, we demonstrated that pretreatment of rat cerebellar granule neurons (CGN) with metformin greatly enhanced cell viability against glutamate-induced neurotoxicity. Metformin significantly attenuated neuronal apoptosis in glutamate-treated CGN by reducing cytochrome c releasing, caspase-3 activation and phosphorylation of MAP kinases. Our results suggested that metformin was able to directly inhibit glutamate induced excitotoxicity in neurons and might be beneficial to patients suffered from stroke and neurodegenerative disorders.

UI MeSH Term Description Entries
D008297 Male Males
D008687 Metformin A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289) Dimethylguanylguanidine,Dimethylbiguanidine,Glucophage,Metformin HCl,Metformin Hydrochloride,HCl, Metformin,Hydrochloride, Metformin
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D002531 Cerebellum The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills. Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000831 Animals, Newborn Refers to animals in the period of time just after birth. Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D017209 Apoptosis A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Apoptosis, Extrinsic Pathway,Apoptosis, Intrinsic Pathway,Caspase-Dependent Apoptosis,Classic Apoptosis,Classical Apoptosis,Programmed Cell Death,Programmed Cell Death, Type I,Apoptoses, Extrinsic Pathway,Apoptoses, Intrinsic Pathway,Apoptosis, Caspase-Dependent,Apoptosis, Classic,Apoptosis, Classical,Caspase Dependent Apoptosis,Cell Death, Programmed,Classic Apoptoses,Extrinsic Pathway Apoptoses,Extrinsic Pathway Apoptosis,Intrinsic Pathway Apoptoses,Intrinsic Pathway Apoptosis

Related Publications

Changwei Zhou, and Rong Sun, and Sujuan Zhuang, and Chongyi Sun, and Yongqing Jiang, and Yang Cui, and Shitou Li, and Yanqiu Xiao, and Yansheng Du, and Huiying Gu, and Qingpeng Liu
Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity.
September 2008, Neuroscience,
Changwei Zhou, and Rong Sun, and Sujuan Zhuang, and Chongyi Sun, and Yongqing Jiang, and Yang Cui, and Shitou Li, and Yanqiu Xiao, and Yansheng Du, and Huiying Gu, and Qingpeng Liu
[Interleukin-6 prevents cultured cerebellar granule neurons from glutamate-induced neurotoxicity].
August 2006, Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
Changwei Zhou, and Rong Sun, and Sujuan Zhuang, and Chongyi Sun, and Yongqing Jiang, and Yang Cui, and Shitou Li, and Yanqiu Xiao, and Yansheng Du, and Huiying Gu, and Qingpeng Liu
Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity.
February 2005, Neuroscience letters,
Changwei Zhou, and Rong Sun, and Sujuan Zhuang, and Chongyi Sun, and Yongqing Jiang, and Yang Cui, and Shitou Li, and Yanqiu Xiao, and Yansheng Du, and Huiying Gu, and Qingpeng Liu
AMPA prevents glutamate-induced neurotoxicity and apoptosis in cultured cerebellar granule cell neurons.
January 2000, Neurotoxicity research,
Changwei Zhou, and Rong Sun, and Sujuan Zhuang, and Chongyi Sun, and Yongqing Jiang, and Yang Cui, and Shitou Li, and Yanqiu Xiao, and Yansheng Du, and Huiying Gu, and Qingpeng Liu
Albumin protects cultured cerebellar granule neurons against zinc neurotoxicity.
September 2005, Neuroreport,
Changwei Zhou, and Rong Sun, and Sujuan Zhuang, and Chongyi Sun, and Yongqing Jiang, and Yang Cui, and Shitou Li, and Yanqiu Xiao, and Yansheng Du, and Huiying Gu, and Qingpeng Liu
Pigment epithelium-derived factor protects cultured cerebellar granule cells against glutamate-induced neurotoxicity.
January 1997, Journal of neurochemistry,
Changwei Zhou, and Rong Sun, and Sujuan Zhuang, and Chongyi Sun, and Yongqing Jiang, and Yang Cui, and Shitou Li, and Yanqiu Xiao, and Yansheng Du, and Huiying Gu, and Qingpeng Liu
Thymoquinone prevents β-amyloid neurotoxicity in primary cultured cerebellar granule neurons.
November 2013, Cellular and molecular neurobiology,
Changwei Zhou, and Rong Sun, and Sujuan Zhuang, and Chongyi Sun, and Yongqing Jiang, and Yang Cui, and Shitou Li, and Yanqiu Xiao, and Yansheng Du, and Huiying Gu, and Qingpeng Liu
CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons.
February 2003, Journal of molecular neuroscience : MN,
Changwei Zhou, and Rong Sun, and Sujuan Zhuang, and Chongyi Sun, and Yongqing Jiang, and Yang Cui, and Shitou Li, and Yanqiu Xiao, and Yansheng Du, and Huiying Gu, and Qingpeng Liu
Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons.
February 2001, Neuroscience letters,
Changwei Zhou, and Rong Sun, and Sujuan Zhuang, and Chongyi Sun, and Yongqing Jiang, and Yang Cui, and Shitou Li, and Yanqiu Xiao, and Yansheng Du, and Huiying Gu, and Qingpeng Liu
Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons.
January 2002, Brain research,
Copied contents to your clipboard!