BIOMAT Database Logo BIOMAT Database Logo

Effect of Resorbable Collagen Plug on Bone Regeneration in Rat Critical-Size Defect Model. 2016

Weiqing Liu, and Ning Kang, and Yuliang Dong, and Yuchen Guo, and Dan Zhao, and Shiwen Zhang, and Liyan Zhou, and Dutmanee Seriwatanachai, and Xing Liang, and Quan Yuan
*Graduate Student, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China. †Lecturer, Dental Implant Center, West China Hospital of Stomatology, Sichuan University, Chengdu, China. ‡Assistant Professor, Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. §Professor, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China.

OBJECTIVE The purpose of this investigation was to examine the effect of resorbable collagen plug (RCP) on bone regeneration in rat calvarial critical-size defects. METHODS About 5-mm-diameter calvarial defects were created in forty 12-week-old male Sprague-Dawley rats and implanted with or without RCP. Animals were killed at 1, 2, 4, and 8 weeks postoperatively. After being killed, specimens were collected and subjected to micro-computed tomography (μCT) and histological analysis. RESULTS The μCT showed a significant increase of newly formed bone volume/tissue volume in RCP-implanted defect compared with controls at all designated time points. After 8 weeks, the defects implanted with RCP displayed almost complete closure. Hematoxylin and eosin staining of the decalcified sections confirmed these observations and evidenced active bone regeneration in the RCP group. In addition, Masson's trichrome staining demonstrated that RCP implantation accelerated the process of collagen maturation. CONCLUSIONS The RCP enhances bone regeneration in rat critical-size cranial defects, which suggest it might be a desired material for bone defect repair.

UI MeSH Term Description Entries
D008297 Male Males
D001861 Bone Regeneration Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone. Osteoconduction,Bone Regenerations,Regeneration, Bone,Regenerations, Bone
D003094 Collagen A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH). Avicon,Avitene,Collagen Felt,Collagen Fleece,Collagenfleece,Collastat,Dermodress,Microfibril Collagen Hemostat,Pangen,Zyderm,alpha-Collagen,Collagen Hemostat, Microfibril,alpha Collagen
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012886 Skull The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN. Calvaria,Cranium,Calvarium,Skulls
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Weiqing Liu, and Ning Kang, and Yuliang Dong, and Yuchen Guo, and Dan Zhao, and Shiwen Zhang, and Liyan Zhou, and Dutmanee Seriwatanachai, and Xing Liang, and Quan Yuan
Evaluation of bone regeneration using the rat critical size calvarial defect.
October 2012, Nature protocols,
Weiqing Liu, and Ning Kang, and Yuliang Dong, and Yuchen Guo, and Dan Zhao, and Shiwen Zhang, and Liyan Zhou, and Dutmanee Seriwatanachai, and Xing Liang, and Quan Yuan
Metformin-Incorporated Gelatin/Nano-Hydroxyapatite Scaffolds Promotes Bone Regeneration in Critical Size Rat Alveolar Bone Defect Model.
January 2022, International journal of molecular sciences,
Weiqing Liu, and Ning Kang, and Yuliang Dong, and Yuchen Guo, and Dan Zhao, and Shiwen Zhang, and Liyan Zhou, and Dutmanee Seriwatanachai, and Xing Liang, and Quan Yuan
Dose effect of dual delivery of vascular endothelial growth factor and bone morphogenetic protein-2 on bone regeneration in a rat critical-size defect model.
September 2009, Tissue engineering. Part A,
Weiqing Liu, and Ning Kang, and Yuliang Dong, and Yuchen Guo, and Dan Zhao, and Shiwen Zhang, and Liyan Zhou, and Dutmanee Seriwatanachai, and Xing Liang, and Quan Yuan
[Early constant observation of the effect of deferoxamine mesylate on improvement of vascularized bone regeneration in SD rat skull critical size defect model].
December 2021, Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences,
Weiqing Liu, and Ning Kang, and Yuliang Dong, and Yuchen Guo, and Dan Zhao, and Shiwen Zhang, and Liyan Zhou, and Dutmanee Seriwatanachai, and Xing Liang, and Quan Yuan
Effect of rhBMP-2 dose on bone formation/maturation in a rat critical-size calvarial defect model.
August 2014, Journal of clinical periodontology,
Weiqing Liu, and Ning Kang, and Yuliang Dong, and Yuchen Guo, and Dan Zhao, and Shiwen Zhang, and Liyan Zhou, and Dutmanee Seriwatanachai, and Xing Liang, and Quan Yuan
Exploratory study on the effect of osteoactivin on bone formation in the rat critical-size calvarial defect model.
April 2012, Journal of periodontal research,
Weiqing Liu, and Ning Kang, and Yuliang Dong, and Yuchen Guo, and Dan Zhao, and Shiwen Zhang, and Liyan Zhou, and Dutmanee Seriwatanachai, and Xing Liang, and Quan Yuan
3D-cultured small size adipose-derived stem cell spheroids promote bone regeneration in the critical-sized bone defect rat model.
May 2022, Biochemical and biophysical research communications,
Weiqing Liu, and Ning Kang, and Yuliang Dong, and Yuchen Guo, and Dan Zhao, and Shiwen Zhang, and Liyan Zhou, and Dutmanee Seriwatanachai, and Xing Liang, and Quan Yuan
Guided bone regeneration in calvarial critical size bony defect using a double-layer resorbable collagen membrane covering a xenograft: a histological and histomorphometric study in rats.
June 2018, Oral and maxillofacial surgery,
Weiqing Liu, and Ning Kang, and Yuliang Dong, and Yuchen Guo, and Dan Zhao, and Shiwen Zhang, and Liyan Zhou, and Dutmanee Seriwatanachai, and Xing Liang, and Quan Yuan
The Impact of Defect Size on Bone Healing in Critical-Size Bone Defects Investigated on a Rat Femur Defect Model Comparing Two Treatment Methods.
March 2024, Bioengineering (Basel, Switzerland),
Weiqing Liu, and Ning Kang, and Yuliang Dong, and Yuchen Guo, and Dan Zhao, and Shiwen Zhang, and Liyan Zhou, and Dutmanee Seriwatanachai, and Xing Liang, and Quan Yuan
Bone regeneration induced by a 3D architectured hydrogel in a rat critical-size calvarial defect.
January 2017, Biomaterials,
Copied contents to your clipboard!