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In this prospective, randomized study the clinical response and toxicity of megestrol acetate (MA) and aminoglutethimide (AG) as second-line treatment in patients with metastatic breast cancer was compared. 176 patients were included, and 150 received treatment greater than 8 weeks and are evaluable for treatment response. The two groups did not differ with regard to prognostic factors. Response rate for the AG and MA groups were 34% and 31% respectively, with duration of response of 13.1 and 13.0 months. Stable disease was obtained in 33% and 35% respectively. No difference was observed in survival. Side effects occurred more frequently in the AG group (42%) than in the MA group (18%).
S Lundgren, and
S Gundersen, and
R Klepp, and
P E Lønning, and
E Lund, and
S Kvinnsland
November 1987,
Cancer,
S Lundgren, and
S Gundersen, and
R Klepp, and
P E Lønning, and
E Lund, and
S Kvinnsland
June 1977,
Annals of internal medicine,
S Lundgren, and
S Gundersen, and
R Klepp, and
P E Lønning, and
E Lund, and
S Kvinnsland
February 1985,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
S Lundgren, and
S Gundersen, and
R Klepp, and
P E Lønning, and
E Lund, and
S Kvinnsland
January 1992,
Oncology,
S Lundgren, and
S Gundersen, and
R Klepp, and
P E Lønning, and
E Lund, and
S Kvinnsland
January 1990,
Cancer chemotherapy and pharmacology,
S Lundgren, and
S Gundersen, and
R Klepp, and
P E Lønning, and
E Lund, and
S Kvinnsland
January 1994,
Oncology,
S Lundgren, and
S Gundersen, and
R Klepp, and
P E Lønning, and
E Lund, and
S Kvinnsland
November 1994,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
S Lundgren, and
S Gundersen, and
R Klepp, and
P E Lønning, and
E Lund, and
S Kvinnsland
August 1982,
Cancer research,
S Lundgren, and
S Gundersen, and
R Klepp, and
P E Lønning, and
E Lund, and
S Kvinnsland
April 1987,
Seminars in hematology,
S Lundgren, and
S Gundersen, and
R Klepp, and
P E Lønning, and
E Lund, and
S Kvinnsland
December 1982,
Cancer,
