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In this double-blind trial, the anticaries effectiveness of a test toothpaste formulated for young children with 550 ppm F was compared with that of a positive control toothpaste containing 1055 ppm fluoride. More than 3000 2-year-old children were enrolled in the study and after 3 years of toothpaste use, 2177 (72 per cent) were examined. From a clinical and radiographic assessment, more than half the children were found to be caries free and only 32 (1.5 per cent) had evidence of rampant caries. There appeared to be little or no difference between children who had used test or control pastes, either in caries or in plaque levels. On the basis of this clinical trial the experimental toothpaste with 550 ppm fluoride would appear to have a similar anticaries efficacy to that of the control toothpaste. Differences were seen in relation to sex of the child and to social class. Girls had lower levels of plaque than boys but more carious teeth. Children from families in higher social classes had fewer carious teeth and lower levels of plaque.
G B Winter, and
R D Holt, and
B F Williams
February 2014,
Journal of the American Dental Association (1939),
G B Winter, and
R D Holt, and
B F Williams
July 1994,
British dental journal,
G B Winter, and
R D Holt, and
B F Williams
August 1990,
Indian pediatrics,
G B Winter, and
R D Holt, and
B F Williams
May 1999,
British dental journal,
G B Winter, and
R D Holt, and
B F Williams
November 2017,
International journal of paediatric dentistry,
G B Winter, and
R D Holt, and
B F Williams
September 1999,
Shanghai kou qiang yi xue = Shanghai journal of stomatology,
G B Winter, and
R D Holt, and
B F Williams
July 2016,
Clinical oral investigations,
G B Winter, and
R D Holt, and
B F Williams
June 2023,
European journal of oral sciences,
G B Winter, and
R D Holt, and
B F Williams
May 2013,
International journal of paediatric dentistry,
G B Winter, and
R D Holt, and
B F Williams
August 1981,
British dental journal,
