BIOMAT Database Logo BIOMAT Database Logo

Synthesis, characterization, and antibacterial property of novel starch derivatives with 1,2,3-triazole. 2016

Wenqiang Tan, and Qing Li, and Huali Wang, and Yan Liu, and Jingjing Zhang, and Fang Dong, and Zhanyong Guo
Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Four novel starch-linked-1,2,3-triazole derivatives were synthesized including 6-hydroxymethyltriazole-6-deoxy starch (HMTST), 6-bromomethyltriazole-6-deoxy starch (BMTST), 6-chloromethyltriazole-6-deoxy starch (CMTST), and 6-carboxyltriazole-6-deoxy starch (CBTST). Their antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were evaluated in vitro, respectively. The inhibitory property of the obtained amphiprotic starch derivatives exhibited a remarkable improvement over starch. And the antibacterial indices of most of the products were higher than 60% and 40% at 1.0 mg/mL when the culture time was 8 h and 16 h, respectively. Moreover, the inhibitory index of CBTST attained 97% above at 1.0 mg/mL. Generally, the inhibitory activity decreased in the order: CBTST>CMTST>BMTST>HMTST>starch. Furthermore, the order of their antibacterial activity was consistent with the electron-withdrawing property of different substituted groups of the 1,2,3-triazole groups. The substituted groups with stronger electron withdrawing ability relatively possessed greater antibacterial activity.

UI MeSH Term Description Entries
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D004926 Escherichia coli A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc. Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D004927 Escherichia coli Infections Infections with bacteria of the species ESCHERICHIA COLI. E coli Infections,E. coli Infection,Infections, E coli,Infections, Escherichia coli,E coli Infection,E. coli Infections,Escherichia coli Infection,Infection, E coli,Infection, E. coli,Infection, Escherichia coli
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D013203 Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS. Infections, Staphylococcal,Staphylococcus aureus Infection,Staphylococcal Infection,Staphylococcus aureus Infections
D013211 Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
D013213 Starch Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants. Amylomaize Starch,Amylum,Cornstarch,Keoflo,Starch, Amylomaize
D014230 Triazoles Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3. Triazole
D057930 Click Chemistry Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries. Click Chemical Reactions,Click Chemical Techniques,Chemical Reaction, Click,Chemical Reactions, Click,Chemical Technique, Click,Chemical Techniques, Click,Chemistries, Click,Chemistry, Click,Click Chemical Reaction,Click Chemical Technique,Click Chemistries,Reaction, Click Chemical,Reactions, Click Chemical,Technique, Click Chemical,Techniques, Click Chemical

Related Publications

Wenqiang Tan, and Qing Li, and Huali Wang, and Yan Liu, and Jingjing Zhang, and Fang Dong, and Zhanyong Guo
Synthesis and Antioxidant Activity of Cationic 1,2,3-Triazole Functionalized Starch Derivatives.
January 2020, Polymers,
Wenqiang Tan, and Qing Li, and Huali Wang, and Yan Liu, and Jingjing Zhang, and Fang Dong, and Zhanyong Guo
Synthesis and antifungal activity of the novel triazole derivatives containing 1,2,3-triazole fragment.
October 2013, Archives of pharmacal research,
Wenqiang Tan, and Qing Li, and Huali Wang, and Yan Liu, and Jingjing Zhang, and Fang Dong, and Zhanyong Guo
Synthesis of glucosylated 1,2,3-triazole derivatives.
February 1999, Carbohydrate research,
Wenqiang Tan, and Qing Li, and Huali Wang, and Yan Liu, and Jingjing Zhang, and Fang Dong, and Zhanyong Guo
Synthesis and Characterization of Azido-Functionalized 1,2,3-Triazole and Fused 1,2,3-Triazole.
April 2023, The Journal of organic chemistry,
Wenqiang Tan, and Qing Li, and Huali Wang, and Yan Liu, and Jingjing Zhang, and Fang Dong, and Zhanyong Guo
Synthesis and antibacterial activity of novel 4-aryl-[1,2,3]-triazole containing macrolides.
January 2011, Bioorganic & medicinal chemistry letters,
Wenqiang Tan, and Qing Li, and Huali Wang, and Yan Liu, and Jingjing Zhang, and Fang Dong, and Zhanyong Guo
Design, Synthesis, and Antifungal Activity of Novel 2-Ar-1,2,3-Triazole Derivatives.
November 2023, Journal of agricultural and food chemistry,
Wenqiang Tan, and Qing Li, and Huali Wang, and Yan Liu, and Jingjing Zhang, and Fang Dong, and Zhanyong Guo
Synthesis, antifungal and antibacterial activity of novel 1,2,4-triazole derivatives.
January 2015, Journal of advanced pharmaceutical technology & research,
Wenqiang Tan, and Qing Li, and Huali Wang, and Yan Liu, and Jingjing Zhang, and Fang Dong, and Zhanyong Guo
1,2,3-Triazole Derivatives as Novel Antifibrinolytic Drugs.
November 2022, International journal of molecular sciences,
Wenqiang Tan, and Qing Li, and Huali Wang, and Yan Liu, and Jingjing Zhang, and Fang Dong, and Zhanyong Guo
Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains.
July 2014, European journal of medicinal chemistry,
Wenqiang Tan, and Qing Li, and Huali Wang, and Yan Liu, and Jingjing Zhang, and Fang Dong, and Zhanyong Guo
Synthesis of thermally stable energetic 1,2,3-triazole derivatives.
January 2013, Chemistry (Weinheim an der Bergstrasse, Germany),
Copied contents to your clipboard!