BIOMAT Database Logo BIOMAT Database Logo

dFoxO promotes Wingless signaling in Drosophila. 2016

Shiping Zhang, and Xiaowei Guo, and Changyan Chen, and Yujun Chen, and Jikai Li, and Ying Sun, and Chenxi Wu, and Yang Yang, and Cizhong Jiang, and Wenzhe Li, and Lei Xue
Institute of Intervention Vessel, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Diseases Research, School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China.

The Wnt/β-catenin signaling is an evolutionarily conserved pathway that regulates a wide range of physiological functions, including embryogenesis, organ maintenance, cell proliferation and cell fate decision. Dysregulation of Wnt/β-catenin signaling has been implicated in various cancers, but its role in cell death has not yet been fully elucidated. Here we show that activation of Wg signaling induces cell death in Drosophila eyes and wings, which depends on dFoxO, a transcription factor known to be involved in cell death. In addition, dFoxO is required for ectopic and endogenous Wg signaling to regulate wing patterning. Moreover, dFoxO is necessary for activated Wg signaling-induced target genes expression. Furthermore, Arm is reciprocally required for dFoxO-induced cell death. Finally, dFoxO physically interacts with Arm both in vitro and in vivo. Thus, we have characterized a previously unknown role of dFoxO in promoting Wg signaling, and that a dFoxO-Arm complex is likely involved in their mutual functions, e.g. cell death.

UI MeSH Term Description Entries
D004331 Drosophila melanogaster A species of fruit fly frequently used in genetics because of the large size of its chromosomes. D. melanogaster,Drosophila melanogasters,melanogaster, Drosophila
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014157 Transcription Factors Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. Transcription Factor,Factor, Transcription,Factors, Transcription
D015398 Signal Transduction The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal
D051155 Wnt1 Protein A proto-oncogene protein and member of the Wnt family of proteins. It is expressed in the caudal MIDBRAIN and is essential for proper development of the entire mid-/hindbrain region. Proto-Oncogene Protein Int-1,Proto-Oncogene Protein Wnt-1,Wnt1 Proto-Oncogene Protein,Wnt-1 Protein,c-int Protein,Int-1, Proto-Oncogene Protein,Proto Oncogene Protein Int 1,Proto Oncogene Protein Wnt 1,Proto-Oncogene Protein, Wnt1,Wnt 1 Protein,Wnt-1, Proto-Oncogene Protein,Wnt1 Proto Oncogene Protein
D051186 Armadillo Domain Proteins A family of proteins that contain several 42-amino acid repeat domains and are homologous to the Drosophila armadillo protein. They bind to other proteins through their armadillo domains and play a variety of roles in the CELL including SIGNAL TRANSDUCTION, regulation of DESMOSOME assembly, and CELL ADHESION. Armadillo Protein,Arm Motif Proteins,Armadillo Motif Proteins,Armadillo Protein Family,Armadillo Proteins,Armadillo Repeat Containing Proteins,Protein, Armadillo
D051858 Forkhead Transcription Factors A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila. Forkhead Box Protein,Forkhead Box Transcription Factor,Forkhead Protein,Forkhead Transcription Factor,Forkhead Box Proteins,Forkhead Box Transcription Factors,Forkhead Proteins,Fox Transcription Factors,Box Protein, Forkhead,Box Proteins, Forkhead,Factor, Forkhead Transcription,Protein, Forkhead,Protein, Forkhead Box,Proteins, Forkhead Box,Transcription Factor, Forkhead,Transcription Factors, Forkhead,Transcription Factors, Fox
D029721 Drosophila Proteins Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. Drosophila melanogaster Proteins,Proteins, Drosophila,Proteins, Drosophila melanogaster,melanogaster Proteins, Drosophila

Related Publications

Shiping Zhang, and Xiaowei Guo, and Changyan Chen, and Yujun Chen, and Jikai Li, and Ying Sun, and Chenxi Wu, and Yang Yang, and Cizhong Jiang, and Wenzhe Li, and Lei Xue
APLP1 promotes dFoxO-dependent cell death in Drosophila.
June 2015, Apoptosis : an international journal on programmed cell death,
Shiping Zhang, and Xiaowei Guo, and Changyan Chen, and Yujun Chen, and Jikai Li, and Ying Sun, and Chenxi Wu, and Yang Yang, and Cizhong Jiang, and Wenzhe Li, and Lei Xue
Wnt/Wingless signaling in Drosophila.
June 2012, Cold Spring Harbor perspectives in biology,
Shiping Zhang, and Xiaowei Guo, and Changyan Chen, and Yujun Chen, and Jikai Li, and Ying Sun, and Chenxi Wu, and Yang Yang, and Cizhong Jiang, and Wenzhe Li, and Lei Xue
Signaling by wingless in Drosophila.
December 1994, Developmental biology,
Shiping Zhang, and Xiaowei Guo, and Changyan Chen, and Yujun Chen, and Jikai Li, and Ying Sun, and Chenxi Wu, and Yang Yang, and Cizhong Jiang, and Wenzhe Li, and Lei Xue
Wingless signaling in Drosophila eye development.
January 2008, Methods in molecular biology (Clifton, N.J.),
Shiping Zhang, and Xiaowei Guo, and Changyan Chen, and Yujun Chen, and Jikai Li, and Ying Sun, and Chenxi Wu, and Yang Yang, and Cizhong Jiang, and Wenzhe Li, and Lei Xue
JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila.
December 2006, Development (Cambridge, England),
Shiping Zhang, and Xiaowei Guo, and Changyan Chen, and Yujun Chen, and Jikai Li, and Ying Sun, and Chenxi Wu, and Yang Yang, and Cizhong Jiang, and Wenzhe Li, and Lei Xue
dFOXO-independent effects of reduced insulin-like signaling in Drosophila.
October 2011, Aging cell,
Shiping Zhang, and Xiaowei Guo, and Changyan Chen, and Yujun Chen, and Jikai Li, and Ying Sun, and Chenxi Wu, and Yang Yang, and Cizhong Jiang, and Wenzhe Li, and Lei Xue
Function of the wingless signaling pathway in Drosophila.
January 2008, Methods in molecular biology (Clifton, N.J.),
Shiping Zhang, and Xiaowei Guo, and Changyan Chen, and Yujun Chen, and Jikai Li, and Ying Sun, and Chenxi Wu, and Yang Yang, and Cizhong Jiang, and Wenzhe Li, and Lei Xue
Modulation of wingless signaling by Notch in Drosophila.
September 1994, Mechanisms of development,
Shiping Zhang, and Xiaowei Guo, and Changyan Chen, and Yujun Chen, and Jikai Li, and Ying Sun, and Chenxi Wu, and Yang Yang, and Cizhong Jiang, and Wenzhe Li, and Lei Xue
Requirement for Pangolin/dTCF in Drosophila Wingless signaling.
May 2003, Proceedings of the National Academy of Sciences of the United States of America,
Shiping Zhang, and Xiaowei Guo, and Changyan Chen, and Yujun Chen, and Jikai Li, and Ying Sun, and Chenxi Wu, and Yang Yang, and Cizhong Jiang, and Wenzhe Li, and Lei Xue
Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila.
August 1997, Development (Cambridge, England),
Copied contents to your clipboard!