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Addition of the potent tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), to murine erythroleukemia cell lines in suspension cultures inhibited both spontaneous differentiation and differentiation induced by hexamethylene bisacetamide (HMBA), dimethyl sulfoxide, or butyric acid. Inhibition was unrelated to cytotoxicity and was reversible. When several plant diterpenes were tested, there was a positive correlation between tumor-promoting activity and inhibition of differentiation. TPA inhibited HMBA-induced differentiation only if added prior to the time of commitment to differentiation, as assayed by scoring for differentiation after transfer of cells from HMBA to fresh medium without HMBA. TPA-mediated inhibition of differentiation was associated with a decrease in globin mRNA accumulation.
H Yamasaki, and
E Fibach, and
U Nudel, and
I B Weinstein, and
R A Rifkind, and
P A Marks
July 1977,
Proceedings of the National Academy of Sciences of the United States of America,
H Yamasaki, and
E Fibach, and
U Nudel, and
I B Weinstein, and
R A Rifkind, and
P A Marks
June 1980,
Biochemical and biophysical research communications,
H Yamasaki, and
E Fibach, and
U Nudel, and
I B Weinstein, and
R A Rifkind, and
P A Marks
October 1987,
Molecular and cellular biochemistry,
H Yamasaki, and
E Fibach, and
U Nudel, and
I B Weinstein, and
R A Rifkind, and
P A Marks
December 1986,
Cancer research,
H Yamasaki, and
E Fibach, and
U Nudel, and
I B Weinstein, and
R A Rifkind, and
P A Marks
February 1993,
Blood,
H Yamasaki, and
E Fibach, and
U Nudel, and
I B Weinstein, and
R A Rifkind, and
P A Marks
January 1984,
Advances in cancer research,
H Yamasaki, and
E Fibach, and
U Nudel, and
I B Weinstein, and
R A Rifkind, and
P A Marks
September 1988,
Molecular and cellular biology,
H Yamasaki, and
E Fibach, and
U Nudel, and
I B Weinstein, and
R A Rifkind, and
P A Marks
March 1981,
Experimental cell research,
H Yamasaki, and
E Fibach, and
U Nudel, and
I B Weinstein, and
R A Rifkind, and
P A Marks
November 1978,
Life sciences,
H Yamasaki, and
E Fibach, and
U Nudel, and
I B Weinstein, and
R A Rifkind, and
P A Marks
December 1979,
Proceedings of the National Academy of Sciences of the United States of America,
