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The stereoselectivity of the interaction with muscarinic receptors of enantiomers of a series of chiral antagonists is receptor subtype dependent. There is no overall relationship between stereoselectivity and receptor affinity. Depending on the antagonist studied, receptor stereoselectivity may indeed reflect: (1) the weakening or loss of a single interaction involving one of the four groups bound to the asymmetric carbon; (2) steric hindrance preventing optimum interaction of the low affinity steroisomer with the receptor; and/or (3) the inversion of the relative positions of two moieties of the ligand with similar structural and electronic properties i.e. comparable affinities for the two corresponding subsites in the receptor.
M Waelbroeck, and
M Tastenoy, and
J Camus, and
R Feifel, and
E Mutschler, and
C Strohmann, and
R Tacke, and
G Lambrecht, and
J Christophe
May 1987,
Clinical and experimental pharmacology & physiology,
M Waelbroeck, and
M Tastenoy, and
J Camus, and
R Feifel, and
E Mutschler, and
C Strohmann, and
R Tacke, and
G Lambrecht, and
J Christophe
September 1987,
Biochemical pharmacology,
M Waelbroeck, and
M Tastenoy, and
J Camus, and
R Feifel, and
E Mutschler, and
C Strohmann, and
R Tacke, and
G Lambrecht, and
J Christophe
January 1989,
Naunyn-Schmiedeberg's archives of pharmacology,
M Waelbroeck, and
M Tastenoy, and
J Camus, and
R Feifel, and
E Mutschler, and
C Strohmann, and
R Tacke, and
G Lambrecht, and
J Christophe
April 1978,
Brain research,
M Waelbroeck, and
M Tastenoy, and
J Camus, and
R Feifel, and
E Mutschler, and
C Strohmann, and
R Tacke, and
G Lambrecht, and
J Christophe
December 2009,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
M Waelbroeck, and
M Tastenoy, and
J Camus, and
R Feifel, and
E Mutschler, and
C Strohmann, and
R Tacke, and
G Lambrecht, and
J Christophe
June 1999,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
M Waelbroeck, and
M Tastenoy, and
J Camus, and
R Feifel, and
E Mutschler, and
C Strohmann, and
R Tacke, and
G Lambrecht, and
J Christophe
September 1978,
Molecular pharmacology,
M Waelbroeck, and
M Tastenoy, and
J Camus, and
R Feifel, and
E Mutschler, and
C Strohmann, and
R Tacke, and
G Lambrecht, and
J Christophe
January 2012,
Mediators of inflammation,
M Waelbroeck, and
M Tastenoy, and
J Camus, and
R Feifel, and
E Mutschler, and
C Strohmann, and
R Tacke, and
G Lambrecht, and
J Christophe
January 2020,
Current Alzheimer research,
M Waelbroeck, and
M Tastenoy, and
J Camus, and
R Feifel, and
E Mutschler, and
C Strohmann, and
R Tacke, and
G Lambrecht, and
J Christophe
January 1980,
British journal of pharmacology,
