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A complete response to BCG is described in a case of recurrent melanoma. In a woman aged 38 years, intracutaneous metastatic deposits confined to the limb of origin had occurred after excision of a malignant melanoma from the ankle, and elective groin dissection had shown two lymph nodes infiltrated with melanoma. BCG vaccine was applied to the buttock, initially by scarification and later by a multiple puncture gun. All metastases slowly regressed, and biopsy of a metastatic site at six months showed no tumour cells. The patient remains free of detectable disease 36 months after the commencement of therapy. It is inferred that BCG may facilitate remission of melanoma, perhaps by reason of antigenic cross-reactivity between BCG and surface components of human melanoma cells.
A S Coates, and
M Peters
October 2003,
Hinyokika kiyo. Acta urologica Japonica,
A S Coates, and
M Peters
January 1995,
International urology and nephrology,
A S Coates, and
M Peters
December 2015,
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences,
A S Coates, and
M Peters
April 2021,
BMJ case reports,
A S Coates, and
M Peters
August 1987,
The Journal of urology,
A S Coates, and
M Peters
August 2010,
BMJ case reports,
A S Coates, and
M Peters
January 1988,
Retina (Philadelphia, Pa.),
A S Coates, and
M Peters
August 1986,
The American Journal of dermatopathology,
A S Coates, and
M Peters
November 1993,
The Journal of dermatologic surgery and oncology,
A S Coates, and
M Peters
October 2010,
Annals of the Royal College of Surgeons of England,
