-transparent.png){kind=logo}
The effects of Mg2+ on Ni(2+)-induced epileptiform bursting activity and input membrane resistance during this activity of leech Retzius neurons were examined using intracellular recordings. To induce epileptiform activity, 3 mmol/l NiCl2 was added into superfusing Ringer (Ri) saline. To test for dose-dependence of the effects of Mg2+ on the induced epileptiform activity, MgCl2 was added in concentrations from 1 mmol/l to 20 mmol/l Mg2+ to the Ni(2+)-containing Ri saline. Input membrane resistance (IMR) was measured in standard Ri, Ni2+ Ri and 20 mmol/l Mg2+Ni2+ Ri saline. Superfusion with Ni2+ Ri induced epileptiform bursting activity characterized by generation of paroxysmal depolarization shifts (PDSs). Parameters of epileptiform activity including PDS frequency, PDS duration, PDS amplitude and the number of spikes/PDS were measured. Magnesium suppressed Ni(2+)-induced epileptiform activity, significantly reducing values of all parameters observed in a concentration-dependent manner. The highest concentration applied of 20 mmol/l Mg2+ completely eliminated epileptiform activity. To test for the effect of Mg2+ on membrane conductance during bursting, IMR was measured. Magnesium significantly increased IMR during bursting suppression.
Marija Stanojević, and
Srdjan Lopicic, and
Zorica Jovanovic, and
Dhruba Pathak, and
Dragan V Pavlovic, and
Svetolik Spasic, and
Vladimir Nedeljkov, and
Milica Prostran
August 1998,
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova,
Marija Stanojević, and
Srdjan Lopicic, and
Zorica Jovanovic, and
Dhruba Pathak, and
Dragan V Pavlovic, and
Svetolik Spasic, and
Vladimir Nedeljkov, and
Milica Prostran
May 2001,
Pflugers Archiv : European journal of physiology,
Marija Stanojević, and
Srdjan Lopicic, and
Zorica Jovanovic, and
Dhruba Pathak, and
Dragan V Pavlovic, and
Svetolik Spasic, and
Vladimir Nedeljkov, and
Milica Prostran
January 2009,
General physiology and biophysics,
Marija Stanojević, and
Srdjan Lopicic, and
Zorica Jovanovic, and
Dhruba Pathak, and
Dragan V Pavlovic, and
Svetolik Spasic, and
Vladimir Nedeljkov, and
Milica Prostran
February 2008,
The Journal of experimental biology,
Marija Stanojević, and
Srdjan Lopicic, and
Zorica Jovanovic, and
Dhruba Pathak, and
Dragan V Pavlovic, and
Svetolik Spasic, and
Vladimir Nedeljkov, and
Milica Prostran
July 1976,
Journal of neurobiology,
Marija Stanojević, and
Srdjan Lopicic, and
Zorica Jovanovic, and
Dhruba Pathak, and
Dragan V Pavlovic, and
Svetolik Spasic, and
Vladimir Nedeljkov, and
Milica Prostran
November 1977,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
Marija Stanojević, and
Srdjan Lopicic, and
Zorica Jovanovic, and
Dhruba Pathak, and
Dragan V Pavlovic, and
Svetolik Spasic, and
Vladimir Nedeljkov, and
Milica Prostran
December 1974,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
Marija Stanojević, and
Srdjan Lopicic, and
Zorica Jovanovic, and
Dhruba Pathak, and
Dragan V Pavlovic, and
Svetolik Spasic, and
Vladimir Nedeljkov, and
Milica Prostran
January 2001,
Physiological research,
Marija Stanojević, and
Srdjan Lopicic, and
Zorica Jovanovic, and
Dhruba Pathak, and
Dragan V Pavlovic, and
Svetolik Spasic, and
Vladimir Nedeljkov, and
Milica Prostran
April 2020,
Brain research,
Marija Stanojević, and
Srdjan Lopicic, and
Zorica Jovanovic, and
Dhruba Pathak, and
Dragan V Pavlovic, and
Svetolik Spasic, and
Vladimir Nedeljkov, and
Milica Prostran
March 1996,
The Journal of physiology,
