The clinical and radiological observations of 115 patients (163 joints) with neuroarthropathy (Charcot joint) were presented. The main clinical and typical X-ray findings as well as the radiologic features of different joints were described: (1) In Charcot joint of the shoulder, the entire scapula bone may be disintegrated; (2) After cleaning and arthrodesis, fragmentation of bone may reappear at both ends of the affected long bone and even the lateral surface of diaphysis; (3) Fragmentation of articular surface and subchondral bone may be seen in non-weight bearing surface; (4) 32 cases in our series had spontaneous fractures without history of trauma or undue strain; (5) Follow-up observation in short period (two to six weeks) showed rapid progressive destruction. The authors were of the opinion that neurotrophic theory seems to be the important pathogenesis of Charcot joint. While bone resorption should be the primary change. Bone hypertrophy and proliferation are secondary changes.