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A series of 2-azetidinone derivatives was synthesized from hippuric acid and evaluated for its in vitro antimicrobial and anticancer activities. Antimicrobial properties of the title compounds were investigated against Gram positive and Gram negative bacterial as well as fungal strains. Anticancer activity was performed against breast cancer (MCF7) cell lines. Antimicrobial activity results revealed that N-{2-[3-chloro-2-(2- chlorophenyl)-4-oxoazetidin-1-ylamino]-2-oxoethyl}benzamide (4) was found to be the most potent antimicrobial agent. Results of anticancer study indicated that the synthesized compounds exhibited average anticancer potential and N-[2-(3-chloro-2-oxo-4-styrylazetidin-1-ylamino)-2-oxoethyl]benzamide (17) was found to be most potent anticancer agent against breast cancer (MCF7) cell lines. QSAR models indicated that the antibacterial, antifungal and the overall antimicrobial activities of the synthesized compounds were governed by topological parameters, Balaban index (J) and valence zero and first order molecular connectivity indices (⁰χv and ¹χv).
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
January 2015,
Current topics in medicinal chemistry,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
April 2014,
Drug research,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
May 2014,
Drug research,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
February 2014,
Drug research,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
April 2010,
Archiv der Pharmazie,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
January 2014,
Drug research,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
August 2013,
Current topics in medicinal chemistry,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
January 2011,
Acta poloniae pharmaceutica,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
April 2009,
European journal of medicinal chemistry,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
July 2010,
European journal of medicinal chemistry,
