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In this study, a novel series of 4-thiazolidinone derivatives (1-17) was synthesized and evaluated for its in vitro antimicrobial and anticancer potentials. N-(2-(5-(4-nitrobenzylidene)-2-(4-chlorophenyl)-4-oxothia- zolidin-3-ylamino)-2-oxoethyl) benzamide (7, pMICam = 1.86 µM/mL) was found to be the most active antimi- crobial agent. The anticancer study results demonstrated that N-(2-(5-(4-hydroxybenzylidene)-2-(4- methoxyphenyl)-4-oxothiazolidin-3-ylamino)-2-oxoethyl) benzamide (10, IC₅₀ = 18.59 µM) was the most active anticancer agent. QSAR studies indicated the importance of topological parameter, Kier's α third order shape index (κα₃) as well as electronic parameters, cosmic total energy (cos E) and energy of highest occupied molecular orbital (HOMO) in describing the antimicrobial activity of synthesized compounds.
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
August 2013,
Current topics in medicinal chemistry,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
January 2015,
Current topics in medicinal chemistry,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
August 2011,
Organic and medicinal chemistry letters,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
September 2021,
Bioorganic chemistry,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
May 2009,
European journal of medicinal chemistry,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
April 2011,
European journal of medicinal chemistry,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
February 2014,
Drug research,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
December 2010,
Bioorganic & medicinal chemistry letters,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
January 1985,
Il Farmaco; edizione scientifica,
Aakash Deep, and
Pradeep Kumar, and
Balasubramanian Narasimhan, and
Siong Meng Lim, and
Kalavathy Ramasamy, and
Rakesh Kumar Mishra, and
Vasudevan Mani
May 2008,
Medicinal chemistry (Shariqah (United Arab Emirates)),
