BIOMAT Database Logo BIOMAT Database Logo

CLINICAL INFECTION OF CAPTIVE ASIAN ELEPHANTS (ELEPHAS MAXIMUS) WITH ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 4. 2016

Angela Fuery, and Geoffrey R Browning, and Jie Tan, and Simon Long, and Gary S Hayward, and Sherry K Cox, and Joseph P Flanagan, and Maryanne E Tocidlowski, and Lauren L Howard, and Paul D Ling

Elephant endotheliotropic herpesvirus (EEHV) can cause lethal hemorrhagic disease in juvenile Asian elephants. A number of EEHV types and subtypes exist, where most deaths have been caused by EEHV1A and EEHV1B. EEHV4 has been attributed to two deaths, but as both diagnoses were made postmortem, EEHV4 disease has not yet been observed and recorded clinically. In this brief communication, two cases of EEHV4 infection in juvenile elephants at the Houston Zoo are described, where both cases were resolved following intensive treatment and administration of famciclovir. A quantitative real-time polymerase chain reaction detected EEHV4 viremia that correlated with clinical signs. High levels of EEHV4 shedding from trunk wash secretions of the first viremic elephant correlated with subsequent infection of the second elephant with EEHV4. It is hoped that the observations made in these cases--and the successful treatment regimen used--will help other institutions identify and treat EEHV4 infection in the future.

UI MeSH Term Description Entries
D008297 Male Males
D004279 DNA, Viral Deoxyribonucleic acid that makes up the genetic material of viruses. Viral DNA
D004606 Elephants Large mammals in the family Elephantidae, with columnar limbs, bulky bodies, and elongated snouts. They are the only surviving members of the PROBOSCIDEA MAMMALS. African Elephants,Asiatic Elephants,Elephas maximus,Loxodonta,African Elephant,Asiatic Elephant,Elephant,Elephant, African,Elephant, Asiatic,Elephants, African,Elephants, Asiatic
D005260 Female Females
D006564 Herpesviridae A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE. Mouse Thymic Virus,Murid herpesvirus 3,Thymic Group Viruses,Herpesviruses,Mouse Thymic Viruses,Thymic Virus, Mouse,Thymic Viruses, Mouse
D006566 Herpesviridae Infections Virus diseases caused by the HERPESVIRIDAE. Herpesvirus Infections,B Virus Infection,Infections, Herpesviridae,Infections, Herpesvirus,B Virus Infections,Herpesviridae Infection,Herpesvirus Infection,Infection, B Virus,Infection, Herpesviridae,Infection, Herpesvirus,Infections, B Virus
D000077595 Famciclovir An aminopurine derivative and prodrug of penciclovir which is a competitive inhibitor of herpes simplex 2 DNA polymerase. It is used to treat HERPES SIMPLEX VIRUS INFECTION. 1,3-Propanediol, 2-(2-(2-amino-9H-purin-9-yl)ethyl)-, diacetate (ester),9-(4-Acetoxy-3-(acetoxymethyl)but-1-yl)-2-aminopurine,BRL 42810,BRL-42810,Famvir,BRL42810
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000836 Animals, Zoo Animal population groups or individual animals that reside in captivity at a zoological park. Animal, Zoo,Zoo Animal,Zoo Animals
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral

Related Publications

Angela Fuery, and Geoffrey R Browning, and Jie Tan, and Simon Long, and Gary S Hayward, and Sherry K Cox, and Joseph P Flanagan, and Maryanne E Tocidlowski, and Lauren L Howard, and Paul D Ling
CLINICAL INFECTION OF TWO CAPTIVE ASIAN ELEPHANTS (ELEPHAS MAXIMUS) WITH ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 1B.
March 2016, Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians,
Angela Fuery, and Geoffrey R Browning, and Jie Tan, and Simon Long, and Gary S Hayward, and Sherry K Cox, and Joseph P Flanagan, and Maryanne E Tocidlowski, and Lauren L Howard, and Paul D Ling
Subclinical infection of captive Asian elephants (Elephas maximus) in Thailand with elephant endotheliotropic herpesvirus.
February 2020, Archives of virology,
Angela Fuery, and Geoffrey R Browning, and Jie Tan, and Simon Long, and Gary S Hayward, and Sherry K Cox, and Joseph P Flanagan, and Maryanne E Tocidlowski, and Lauren L Howard, and Paul D Ling
Elephant endotheliotropic herpesvirus 5, a newly recognized elephant herpesvirus associated with clinical and subclinical infections in captive Asian elephants (Elephas maximus).
March 2013, Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians,
Angela Fuery, and Geoffrey R Browning, and Jie Tan, and Simon Long, and Gary S Hayward, and Sherry K Cox, and Joseph P Flanagan, and Maryanne E Tocidlowski, and Lauren L Howard, and Paul D Ling
Kinetics of viral loads and genotypic analysis of elephant endotheliotropic herpesvirus-1 infection in captive Asian elephants (Elephas maximus).
March 2013, Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians,
Angela Fuery, and Geoffrey R Browning, and Jie Tan, and Simon Long, and Gary S Hayward, and Sherry K Cox, and Joseph P Flanagan, and Maryanne E Tocidlowski, and Lauren L Howard, and Paul D Ling
Detection of elephant endotheliotropic herpesvirus infection among healthy Asian elephants (Elephas maximus) in South India.
April 2014, Journal of wildlife diseases,
Angela Fuery, and Geoffrey R Browning, and Jie Tan, and Simon Long, and Gary S Hayward, and Sherry K Cox, and Joseph P Flanagan, and Maryanne E Tocidlowski, and Lauren L Howard, and Paul D Ling
Endotheliotropic herpesvirus infection in Asian elephants (Elephas maximus) of Assam, India.
November 2019, Veterinary world,
Angela Fuery, and Geoffrey R Browning, and Jie Tan, and Simon Long, and Gary S Hayward, and Sherry K Cox, and Joseph P Flanagan, and Maryanne E Tocidlowski, and Lauren L Howard, and Paul D Ling
CHANGES IN SERUM CARDIAC TROPONIN I IN ASIAN ELEPHANTS (ELEPHAS MAXIMUS) WITH ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS INFECTION.
June 2022, Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians,
Angela Fuery, and Geoffrey R Browning, and Jie Tan, and Simon Long, and Gary S Hayward, and Sherry K Cox, and Joseph P Flanagan, and Maryanne E Tocidlowski, and Lauren L Howard, and Paul D Ling
The occurrence of elephant endotheliotropic herpesvirus in captive Asian elephants (Elephas maximus): first case of EEHV4 in Asia.
March 2013, Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians,
Angela Fuery, and Geoffrey R Browning, and Jie Tan, and Simon Long, and Gary S Hayward, and Sherry K Cox, and Joseph P Flanagan, and Maryanne E Tocidlowski, and Lauren L Howard, and Paul D Ling
Pathogenesis of hemorrhagic disease caused by elephant endotheliotropic herpesvirus (EEHV) in Asian elephants (Elephas maximus).
June 2021, Scientific reports,
Angela Fuery, and Geoffrey R Browning, and Jie Tan, and Simon Long, and Gary S Hayward, and Sherry K Cox, and Joseph P Flanagan, and Maryanne E Tocidlowski, and Lauren L Howard, and Paul D Ling
Serological evidence of herpesvirus infection in captive Asian elephants (Elephas maximus).
January 1990, Journal of wildlife diseases,
Copied contents to your clipboard!