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New derivatives of 5-nitroimidazole: synthesis and antiparasitic activity. 1989
E Alcalde, and
L Maños, and
I Dinares, and
N Valls, and
J Elguero, and
J A Escario, and
A R Martinez, and
A Igea, and
A Osuna, and
L M Ruiz-Perez
Lab. Quimica Organica, Facultad de Farmacia, Universidad de Barcelona, España.
The synthesis and the antiparasitic evaluation of twelve new 5-nitroimidaole derivatives has been carried out. The most effective compounds were the less hydrophilic pyridinium and imidazolium salts (IV), (V) and (X), and above all the tetrahydropyridine derivatives (XII) and (XIII).
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