BIOMAT Database Logo BIOMAT Database Logo

Inflammatory microenvironment and human papillomavirus-induced carcinogenesis. 2016

Giorgio Mangino, and Maria Vincenza Chiantore, and Marco Iuliano, and Gianna Fiorucci, and Giovanna Romeo
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy.

More than 15% of the global cancer burden is attributable to infectious agents. Pathogens that cause persistent infections are strongly associated with cancer, inflammation being a major component of the chronic infections as revealed by basic, clinical and epidemiological studies. Persistent infection and viral oncoproteins induce specific cellular pathways modifications that promote tumorigenesis. Deregulated and continuous immune response leads to severe tissue and systemic damage, impaired tumor surveillance and consequent carcinogenesis promotion by selecting for metastatic and therapeutically resistant tumor phenotypes. In this review, the role of inflammatory microenvironment in the HPV-induced carcinogenesis is addressed, with a specific focus on the involvement of the immune molecules and microRNAs as well as their delivery through the microvesicle cargo.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D003713 Dendritic Cells Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION). Dendritic Cells, Interdigitating,Interdigitating Cells,Plasmacytoid Dendritic Cells,Veiled Cells,Dendritic Cells, Interstitial,Dendritic Cells, Plasmacytoid,Interdigitating Dendritic Cells,Interstitial Dendritic Cells,Cell, Dendritic,Cell, Interdigitating,Cell, Interdigitating Dendritic,Cell, Interstitial Dendritic,Cell, Plasmacytoid Dendritic,Cell, Veiled,Cells, Dendritic,Cells, Interdigitating,Cells, Interdigitating Dendritic,Cells, Interstitial Dendritic,Cells, Plasmacytoid Dendritic,Cells, Veiled,Dendritic Cell,Dendritic Cell, Interdigitating,Dendritic Cell, Interstitial,Dendritic Cell, Plasmacytoid,Interdigitating Cell,Interdigitating Dendritic Cell,Interstitial Dendritic Cell,Plasmacytoid Dendritic Cell,Veiled Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D059016 Tumor Microenvironment The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth. Cancer Microenvironment,Cancer Microenvironments,Microenvironment, Cancer,Microenvironment, Tumor,Microenvironments, Cancer,Microenvironments, Tumor,Tumor Microenvironments
D027383 Papillomaviridae A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
D030361 Papillomavirus Infections Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression. HPV Infection,Human Papillomavirus Infection,HPV Infections,Human Papillomavirus Infections,Papillomavirus Infection,Papillomavirus Infection, Human,Papillomavirus Infections, Human
D035683 MicroRNAs Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing. RNA, Small Temporal,Small Temporal RNA,miRNA,stRNA,Micro RNA,MicroRNA,Primary MicroRNA,Primary miRNA,miRNAs,pre-miRNA,pri-miRNA,MicroRNA, Primary,RNA, Micro,Temporal RNA, Small,miRNA, Primary,pre miRNA,pri miRNA
D063646 Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years. Tumorigenesis,Oncogenesis,Carcinogeneses,Oncogeneses,Tumorigeneses

Related Publications

Giorgio Mangino, and Maria Vincenza Chiantore, and Marco Iuliano, and Gianna Fiorucci, and Giovanna Romeo
E3 ubiquitin ligases and human papillomavirus-induced carcinogenesis.
April 2014, The Journal of international medical research,
Giorgio Mangino, and Maria Vincenza Chiantore, and Marco Iuliano, and Gianna Fiorucci, and Giovanna Romeo
Telomeres and Telomerase During Human Papillomavirus-Induced Carcinogenesis.
August 2018, Molecular diagnosis & therapy,
Giorgio Mangino, and Maria Vincenza Chiantore, and Marco Iuliano, and Gianna Fiorucci, and Giovanna Romeo
Molecular mechanisms of human papillomavirus-induced carcinogenesis.
January 2009, Public health genomics,
Giorgio Mangino, and Maria Vincenza Chiantore, and Marco Iuliano, and Gianna Fiorucci, and Giovanna Romeo
Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system.
February 2003, Seminars in cancer biology,
Giorgio Mangino, and Maria Vincenza Chiantore, and Marco Iuliano, and Gianna Fiorucci, and Giovanna Romeo
Molecular Mechanisms of Human Papillomavirus Induced Skin Carcinogenesis.
July 2017, Viruses,
Giorgio Mangino, and Maria Vincenza Chiantore, and Marco Iuliano, and Gianna Fiorucci, and Giovanna Romeo
Human papillomavirus transmission and carcinogenesis.
May 1990, The Australian & New Zealand journal of obstetrics & gynaecology,
Giorgio Mangino, and Maria Vincenza Chiantore, and Marco Iuliano, and Gianna Fiorucci, and Giovanna Romeo
Human papillomavirus transmission and carcinogenesis.
February 1991, The Australian & New Zealand journal of obstetrics & gynaecology,
Giorgio Mangino, and Maria Vincenza Chiantore, and Marco Iuliano, and Gianna Fiorucci, and Giovanna Romeo
Human papillomavirus and cervical carcinogenesis.
October 2001, Best practice & research. Clinical obstetrics & gynaecology,
Giorgio Mangino, and Maria Vincenza Chiantore, and Marco Iuliano, and Gianna Fiorucci, and Giovanna Romeo
Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review).
March 2015, Oncology letters,
Giorgio Mangino, and Maria Vincenza Chiantore, and Marco Iuliano, and Gianna Fiorucci, and Giovanna Romeo
The Host-Microbe Interplay in Human Papillomavirus-Induced Carcinogenesis.
July 2019, Microorganisms,
Copied contents to your clipboard!