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Membrane-based mechanisms of mitotic spindle assembly. 2015
Chromosome Instability & Dynamics Laboratory; Instituto de Biologia Molecular e Celular; Universidade do Porto; Porto, Portugal; Instituto de Investigação e Inovação em Saúde - i3S; Universidade do Porto; Porto, Portugal; Present address: Institute for Research in Biomedicine (IRB Barcelona); C/ Baldiri Reixac 10, 08028 Barcelona, Spain.
Chromosome segregation during mitosis is mediated by the mitotic spindle. Formation of this microtubular structure relies on distinct processes such as microtubule nucleation and growth and the consequent focusing of these filaments into spindle poles. Here, we discuss our recent finding that a size-exclusion spindle envelope promotes mitotic fidelity in Drosophila cells in light of distinct spindle assembly mechanisms.
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