BIOMAT Database Logo BIOMAT Database Logo

Synthesis and biological evaluation of novel pyrimidines derived from 6-aryl-5-cyano-2-thiouracil. 2016

Asma Mohamed Mahran, and Nasser Abdelhamid Hassan, and Dalia Ahmed A Osman, and Sherif Shaban Ragab, and Allam Abdelhamid Hassan

Starting from 6-aryl-5-cyano-2-thiouracil derivative 1a-f, a series of novel thiazolo[3,2-a]pyrimidines 4a-f were synthesized. The mechanism and the regioselectivity of the studied reactions are discussed. In addition, a series of tetrahydro-4-H-pyrimido[2,1-b][1,3]thiazines 7a-e and 2-((ethoxymethyl)thio)-4-aryl-1,6-dihydropyrimidines 9b,c,e were synthesized. The anti-microbial activities of some of the prepared compounds were screened, and the results revealed that compounds 3c and 4c were more active than the standard (Ampicillin) against gram positive bacteria (Pseudomonas aeruginosa). Moreover, compounds 4b,e and 3f were found to be good antifungal agents against the studied fungal strains.

UI MeSH Term Description Entries
D011550 Pseudomonas aeruginosa A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection. Bacillus aeruginosus,Bacillus pyocyaneus,Bacterium aeruginosum,Bacterium pyocyaneum,Micrococcus pyocyaneus,Pseudomonas polycolor,Pseudomonas pyocyanea
D004353 Drug Evaluation, Preclinical Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D014498 Uracil One of four nucleotide bases in the nucleic acid RNA.

Related Publications

Asma Mohamed Mahran, and Nasser Abdelhamid Hassan, and Dalia Ahmed A Osman, and Sherif Shaban Ragab, and Allam Abdelhamid Hassan
Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives.
June 2011, Acta pharmaceutica (Zagreb, Croatia),
Asma Mohamed Mahran, and Nasser Abdelhamid Hassan, and Dalia Ahmed A Osman, and Sherif Shaban Ragab, and Allam Abdelhamid Hassan
Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives.
November 2013, European journal of medicinal chemistry,
Asma Mohamed Mahran, and Nasser Abdelhamid Hassan, and Dalia Ahmed A Osman, and Sherif Shaban Ragab, and Allam Abdelhamid Hassan
Synthesis and antiinflammatory activity of 4-amino-2-aryl-5-cyano-6-{3- and 4-(N-phthalimidophenyl)} pyrimidines.
February 2006, European journal of medicinal chemistry,
Asma Mohamed Mahran, and Nasser Abdelhamid Hassan, and Dalia Ahmed A Osman, and Sherif Shaban Ragab, and Allam Abdelhamid Hassan
Synthesis and biological evaluation of novel 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines as potential anti-bacterial agents.
July 2017, Bioorganic & medicinal chemistry letters,
Asma Mohamed Mahran, and Nasser Abdelhamid Hassan, and Dalia Ahmed A Osman, and Sherif Shaban Ragab, and Allam Abdelhamid Hassan
A novel and efficient one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines and their anti-bacterial activity.
June 2009, European journal of medicinal chemistry,
Asma Mohamed Mahran, and Nasser Abdelhamid Hassan, and Dalia Ahmed A Osman, and Sherif Shaban Ragab, and Allam Abdelhamid Hassan
4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation.
June 2007, Bioorganic & medicinal chemistry letters,
Asma Mohamed Mahran, and Nasser Abdelhamid Hassan, and Dalia Ahmed A Osman, and Sherif Shaban Ragab, and Allam Abdelhamid Hassan
Glucopyranosides derived from 6-aryl-5-cyano-2-(methylthio)pyrimidin-4(3H)ones.
January 2002, Nucleosides, nucleotides & nucleic acids,
Asma Mohamed Mahran, and Nasser Abdelhamid Hassan, and Dalia Ahmed A Osman, and Sherif Shaban Ragab, and Allam Abdelhamid Hassan
An efficient three-component, one-pot synthesis of 2-alkylthio-4-amino-5-cyano-6-aryl(alkyl)pyrimidines in water.
August 2012, Molecular diversity,
Asma Mohamed Mahran, and Nasser Abdelhamid Hassan, and Dalia Ahmed A Osman, and Sherif Shaban Ragab, and Allam Abdelhamid Hassan
Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase.
February 2006, Bioorganic chemistry,
Asma Mohamed Mahran, and Nasser Abdelhamid Hassan, and Dalia Ahmed A Osman, and Sherif Shaban Ragab, and Allam Abdelhamid Hassan
The synthesis of 5-halogeno-2-thiouracil and 6-methyl-5-halogeno-2-thiouracil derivatives.
May 1948, Journal of the American Chemical Society,
Copied contents to your clipboard!