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Does acute exposure to aldehydes impair pulmonary function and structure? 2016
Mariana de Abreu, and
Alcendino Cândido Neto, and
Giovanna Carvalho, and
Natalia Vasconcelos Casquillo, and
Niedja Carvalho, and
Renata Okuro, and
Gabriel C Motta Ribeiro, and
Mariana Machado, and
Aléxia Cardozo, and
Aline Santos E Silva, and
Thiago Barboza, and
Luiz Ricardo Vasconcellos, and
Danielle Araujo Rodrigues, and
Luciana Camilo, and
Leticia de A M Carneiro, and
Frederico Jandre, and
Alexandre V Pino, and
Antonio Giannella-Neto, and
Walter A Zin, and
Leonardo Holanda Travassos Corrêa, and
Marcio Nogueira de Souza, and
Alysson R Carvalho
Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil.
Mixtures of anhydrous ethyl alcohol and gasoline substituted for pure gasoline as a fuel in many Brazilian vehicles. Consequently, the concentrations of volatile organic compounds (VOCs) such as ketones, other organic compounds, and particularly aldehydes increased in many Brazilian cities. The current study aims to investigate whether formaldehyde, acetaldehyde, or mixtures of both impair lung function, morphology, inflammatory and redox responses at environmentally relevant concentrations. For such purpose, C57BL/6 mice were exposed to either medical compressed air or to 4 different mixtures of formaldehyde and acetaldehyde. Eight hours later animals were anesthetized, paralyzed and lung mechanics and morphology, inflammatory cells and IL-1β, KC, TNF-α, IL-6, CCL2, MCP-1 contents, superoxide dismutase and catalalase activities were determined. The extra pulmonary respiratory tract was also analyzed. No differences could be detected between any exposed and control groups. In conclusion, no morpho-functional alterations were detected in exposed mice in relation to the control group.
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